ID   RF1_THEKO               Reviewed;         415 AA.
AC   Q5JGK6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Peptide chain release factor subunit 1 {ECO:0000255|HAMAP-Rule:MF_00424};
DE   AltName: Full=Translation termination factor aRF1 {ECO:0000255|HAMAP-Rule:MF_00424};
GN   Name=prf1 {ECO:0000255|HAMAP-Rule:MF_00424}; OrderedLocusNames=TK1239;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
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DR   EMBL; AP006878; BAD85428.1; -; Genomic_DNA.
DR   RefSeq; WP_011250190.1; NC_006624.1.
DR   AlphaFoldDB; Q5JGK6; -.
DR   SMR; Q5JGK6; -.
DR   IntAct; Q5JGK6; 1.
DR   MINT; Q5JGK6; -.
DR   STRING; 69014.TK1239; -.
DR   PRIDE; Q5JGK6; -.
DR   EnsemblBacteria; BAD85428; BAD85428; TK1239.
DR   GeneID; 3234307; -.
DR   KEGG; tko:TK1239; -.
DR   PATRIC; fig|69014.16.peg.1213; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   InParanoid; Q5JGK6; -.
DR   OMA; GQEMEVV; -.
DR   OrthoDB; 32191at2157; -.
DR   PhylomeDB; Q5JGK6; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..415
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143184"
SQ   SEQUENCE   415 AA;  47338 MW;  0087DF7906911AC1 CRC64;
     MSHKSAEMYE LKKKVEELKS YRGRATELVS LYIPAGYDIN KVMQQLREEY GTAQNIKSKS
     TRKNVLGALE RAMQHLKLYK QTPENGLALF VGNVSEQEGV SDIKLWAIVP PEPLNVRLYR
     CDQTFVTEPL EEMLRVKDAY GLITVEKNEA TIGLLRGKRI EVIDELTSNV PGKTRAGGQS
     ARRYERIREQ ETHEFMKRIG EHANKAFLPL LEKGELRGII IGGPGPTKEE FVEGDYLHHE
     LRKKVIGVVD ISYHGEYGLR ELVEKASDIL KDHEAVKERQ LIQEFFKHLV KDTGMITYGE
     KEVRKALELG AVDKLLISEG YDKVRVRAKC NNCGWEELKT MSEGEFHVYK KQLTHCPKCG
     SQNITFEKWD VAEELIKMAE ESGADVEIIS LDTEEGQQFY KAFGGLGAIL RYKIQ