ID   RF1_THEON               Reviewed;         415 AA.
AC   B6YU52;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Peptide chain release factor subunit 1 {ECO:0000255|HAMAP-Rule:MF_00424};
DE   AltName: Full=Translation termination factor aRF1 {ECO:0000255|HAMAP-Rule:MF_00424};
GN   Name=prf1 {ECO:0000255|HAMAP-Rule:MF_00424}; OrderedLocusNames=TON_0507;
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1;
RX   PubMed=18790866; DOI=10.1128/jb.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.-J., Lee J.-H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
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DR   EMBL; CP000855; ACJ15994.1; -; Genomic_DNA.
DR   RefSeq; WP_012571466.1; NC_011529.1.
DR   AlphaFoldDB; B6YU52; -.
DR   SMR; B6YU52; -.
DR   STRING; 523850.TON_0507; -.
DR   EnsemblBacteria; ACJ15994; ACJ15994; TON_0507.
DR   GeneID; 7016804; -.
DR   KEGG; ton:TON_0507; -.
DR   PATRIC; fig|523850.10.peg.508; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   OMA; GQEMEVV; -.
DR   OrthoDB; 32191at2157; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..415
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_1000193545"
SQ   SEQUENCE   415 AA;  47281 MW;  99675A805E285EBD CRC64;
     MSHKSAEMYE LKKKVEELKS YRGRATELVS LYIPAGYDIN KVMQQLREEY GTAQNIKSKS
     TRKNVLGALE RAMQHLKLYR KTPENGLALF VGNVSEQEGV SDIKLWAIVP PEPLKVRLYR
     CDQTFVTEPL EEMLRVKDAY GLITVEKNEA TIGLLRGKRI EVIDDLTSNV PGKTRAGGQS
     ARRYERIREQ ETHEFMKRIA EHAAKAFLPL LEKGELKGII IGGPGPTKEE FVDGDYLHHE
     LRKKVIGVVD ISYHGEYGLR ELVEKASDIL SEHEAVKERK LIQDFFRHLV KDTGLITYGE
     REVRKALELG AVDTLLISEG YDKVRVKAKC NACGWEELKT MSEQEFHVYK KKLTHCPKCG
     SQNISFEKWD VAEELIKLAE ESGAEVEIIS LDTEEGQQFY KAFGGLGAFL RYKIQ