ID   RF1_THEVO               Reviewed;         418 AA.
AC   P58227;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Peptide chain release factor subunit 1;
DE   AltName: Full=Translation termination factor aRF1;
GN   Name=prf1; OrderedLocusNames=TV0588; ORFNames=TVG0577437;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA   Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA   Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT   Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; BA000011; BAB59730.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58227; -.
DR   SMR; P58227; -.
DR   STRING; 273116.14324803; -.
DR   EnsemblBacteria; BAB59730; BAB59730; BAB59730.
DR   KEGG; tvo:TVG0577437; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   OMA; GQEMEVV; -.
DR   PhylomeDB; P58227; -.
DR   Proteomes; UP000001017; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..418
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143187"
SQ   SEQUENCE   418 AA;  47951 MW;  3B72B219563638FA CRC64;
     MYFMADDEQI RRYEFKRALE ELSKLHGRGT ELISLYIPPE KQISDVVAYL RDEYSTSSNI
     KSKSTRKNVL AAIESIMSRL KYYRFPPPNG LVFFVGHIAT RGDQTEMYTK IIEPPEPITT
     FMYKCDSEFH TEMLKAMLDE KEIYGLIVID RKEATVGFLN GTRIEVVENV QSQVPSKHHQ
     GGQSSRRFER LIEIAANEFF KKVGEIANNA FIPRIKEIRA IFLGGPGATK EYFFEKDYLR
     NEVKDKIKDL FDVGYTDESG LRELVEKASE SIKDMKISRE KDLMDRFLRE VKKPDGGLAV
     YGEKAIRDAL EQKMVDLLLI SEGIRRVKYT YKCPTCGEEK TFSEEPSEWP VCDKDGTPLE
     LIGEDDMIED LYKLAKESGA QVEIISDQSD EGKLLKQAFG GLAAVLRFIR KDNVQNVM