ID   RF2_CAMLR               Reviewed;         366 AA.
AC   B9KEY7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Peptide chain release factor 2 {ECO:0000255|HAMAP-Rule:MF_00094};
DE            Short=RF-2 {ECO:0000255|HAMAP-Rule:MF_00094};
GN   Name=prfB {ECO:0000255|HAMAP-Rule:MF_00094}; OrderedLocusNames=Cla_0259;
OS   Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=306263;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM2100 / D67 / ATCC BAA-1060;
RX   PubMed=18713059; DOI=10.1089/fpd.2008.0101;
RA   Miller W.G., Wang G., Binnewies T.T., Parker C.T.;
RT   "The complete genome sequence and analysis of the human pathogen
RT   Campylobacter lari.";
RL   Foodborne Pathog. Dis. 5:371-386(2008).
CC   -!- FUNCTION: Peptide chain release factor 2 directs the termination of
CC       translation in response to the peptide chain termination codons UGA and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00094}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF2. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00094}.
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DR   EMBL; CP000932; ACM63622.1; -; Genomic_DNA.
DR   RefSeq; WP_012661006.1; NC_012039.1.
DR   AlphaFoldDB; B9KEY7; -.
DR   SMR; B9KEY7; -.
DR   STRING; 306263.Cla_0259; -.
DR   EnsemblBacteria; ACM63622; ACM63622; CLA_0259.
DR   GeneID; 7410168; -.
DR   KEGG; cla:CLA_0259; -.
DR   PATRIC; fig|306263.5.peg.257; -.
DR   eggNOG; COG1186; Bacteria.
DR   HOGENOM; CLU_036856_6_0_7; -.
DR   OMA; NKPDLWD; -.
DR   OrthoDB; 928964at2; -.
DR   Proteomes; UP000007727; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00094; Rel_fac_2; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004374; PrfB.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00020; prfB; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis.
FT   CHAIN           1..366
FT                   /note="Peptide chain release factor 2"
FT                   /id="PRO_1000193547"
FT   MOD_RES         251
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00094"
SQ   SEQUENCE   366 AA;  41266 MW;  2F3DD1607461FA18 CRC64;
     MDNYEYSELL KKLKNKVGNI ASIIKPEEIK ARLKEIENLE NSPSFWSDVK QAGIIGKEKT
     KISNLLKNYE NAFNALNDAS ELFDLANSEN DLDTIQALFD DAPNLEDLIV SLEISMLLSG
     ENDGKNAIVS IHPGAGGTES NDWASMLYRM YLRFCEREGF KVETLDFQEG EEAGLKDVSF
     LVKGENAYGY LKAENGIHRL VRTSPFDSAG RRHTSFSSVM VSPELDDDIE IEIEDKDIRI
     DYYRASGAGG QHVNKTESAV RITHMPSGIV VQCQNDRSQH KNKATAFKML KSRLYELELM
     KQQDEANSSE KSEIGWGHQI RSYVLFPYQQ VKDTRSNEAF SQVDNILDGD IKKMIEGVLI
     AQKAQD