RF2_FRACC
ID RF2_FRACC Reviewed; 366 AA.
AC Q2JEW7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Peptide chain release factor 2 {ECO:0000255|HAMAP-Rule:MF_00094};
DE Short=RF-2 {ECO:0000255|HAMAP-Rule:MF_00094};
GN Name=prfB {ECO:0000255|HAMAP-Rule:MF_00094};
GN OrderedLocusNames=Francci3_0791;
OS Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=106370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: Peptide chain release factor 2 directs the termination of
CC translation in response to the peptide chain termination codons UGA and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF2. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00094}.
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DR EMBL; CP000249; ABD10175.1; -; Genomic_DNA.
DR RefSeq; WP_011435244.1; NZ_JENI01000002.1.
DR AlphaFoldDB; Q2JEW7; -.
DR SMR; Q2JEW7; -.
DR STRING; 106370.Francci3_0791; -.
DR EnsemblBacteria; ABD10175; ABD10175; Francci3_0791.
DR KEGG; fra:Francci3_0791; -.
DR eggNOG; COG1186; Bacteria.
DR HOGENOM; CLU_036856_6_0_11; -.
DR OMA; YVFHPYQ; -.
DR OrthoDB; 928964at2; -.
DR PhylomeDB; Q2JEW7; -.
DR Proteomes; UP000001937; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00094; Rel_fac_2; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004374; PrfB.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00020; prfB; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT CHAIN 1..366
FT /note="Peptide chain release factor 2"
FT /id="PRO_1000075525"
FT MOD_RES 246
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00094"
SQ SEQUENCE 366 AA; 40489 MW; 95636E2511E79D74 CRC64;
MAVDLSEEIK QLDATLTGIE TVLDVEGLRR RAEDLERQAA DPDLWSDQDR AQAVTRRLSS
TRGDIARVEG LRRRLDDIAA AADLGDEDLL AEAAADLPRL SSDIAGLEVR TLLSGEYDER
DAIVQLSAGA GGVDAADWTA MLLRMYLRWA ERHGYATEVF DTSEAEEAGL KSATFQVKAP
YAYGTLRSEH GVHRLVRISP FDNQNRRQTS FAGVEVTPVV ELSDHVDIDD KDLRIDIFRS
SGPGGQGVNT TDSAVRITHL PTGIVVTCQN ERSQLQNKAA AMIVLQAKLL ERRRAEEAAE
KQRITGGPQD VSFGSQIRNY VLHPYQMVKD LRTDTETSNT SGVLDGELDD FIDAEIRWRR
SVENQA
