RF2_SULNB
ID RF2_SULNB Reviewed; 364 AA.
AC A6Q718;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Peptide chain release factor 2 {ECO:0000255|HAMAP-Rule:MF_00094};
DE Short=RF-2 {ECO:0000255|HAMAP-Rule:MF_00094};
GN Name=prfB {ECO:0000255|HAMAP-Rule:MF_00094}; OrderedLocusNames=SUN_0317;
OS Sulfurovum sp. (strain NBC37-1).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Sulfurovaceae; Sulfurovum; unclassified Sulfurovum.
OX NCBI_TaxID=387093;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBC37-1;
RX PubMed=17615243; DOI=10.1073/pnas.0700687104;
RA Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K.,
RA Horikoshi K.;
RT "Deep-sea vent epsilon-proteobacterial genomes provide insights into
RT emergence of pathogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007).
CC -!- FUNCTION: Peptide chain release factor 2 directs the termination of
CC translation in response to the peptide chain termination codons UGA and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF2. {ECO:0000255|HAMAP-Rule:MF_00094}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00094}.
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DR EMBL; AP009179; BAF71277.1; -; Genomic_DNA.
DR RefSeq; WP_011980010.1; NC_009663.1.
DR AlphaFoldDB; A6Q718; -.
DR SMR; A6Q718; -.
DR STRING; 387093.SUN_0317; -.
DR EnsemblBacteria; BAF71277; BAF71277; SUN_0317.
DR KEGG; sun:SUN_0317; -.
DR eggNOG; COG1186; Bacteria.
DR HOGENOM; CLU_036856_6_0_7; -.
DR OMA; YVFHPYQ; -.
DR OrthoDB; 928964at2; -.
DR Proteomes; UP000006378; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00094; Rel_fac_2; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004374; PrfB.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00020; prfB; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT CHAIN 1..364
FT /note="Peptide chain release factor 2"
FT /id="PRO_1000005016"
FT MOD_RES 251
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00094"
SQ SEQUENCE 364 AA; 41535 MW; A5491255F8EDF76B CRC64;
MDAYEYGELL KTLSKKMENI SNIVKPDELK KRLDEIEEMQ QDPNFWNDTA NAGKISQEKT
RTERILETYH NANDAVYDAI EYFEMAKAEK DEETLEMLYE DAETLKERTN ALEVQMMLSG
EHDSNNAIVS IHPGAGGTES QDWASMLYRM YLRWAERHGF KVEVLDYQPG EEAGIKDVSF
IIKGENAYGY LKVENGIHRL VRISPFDSNA KRHTSFTSVM VSPEIDDDID IEIEDKDLRI
DTYRASGAGG QHVNKTESAI RITHEPTGIV VQCQNDRSQH KNKSAAMKML KSRLYEYEMA
KKQAEIDGVE KSDIGWGHQI RSYVMQPYQQ VKDTRSGQAF TNVDAILDGD IDKLLEGVLI
SQAK