RFA1C_ARATH
ID RFA1C_ARATH Reviewed; 853 AA.
AC Q9FHJ6;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Replication protein A 70 kDa DNA-binding subunit C;
DE Short=AtRPA70c;
DE AltName: Full=AtRPA1-2;
DE AltName: Full=Replication factor A protein 1C;
DE AltName: Full=Replication protein A 1C;
DE Short=AtRPA1C;
GN Name=RPA1C; Synonyms=RPA70C; OrderedLocusNames=At5g45400; ORFNames=MFC19.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Component of the replication protein A complex (RPA) required
CC for DNA recombination, repair and replication. The activity of RPA is
CC mediated by single-stranded DNA binding and protein interactions.
CC Probably involved in repair of double-strand DNA breaks (DSBs) induced
CC by genotoxic stresses (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimer of RPA1, RPA2 and RPA3 (canonical replication
CC protein A complex). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the replication factor A protein 1 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB018113; BAB09168.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95244.1; -; Genomic_DNA.
DR RefSeq; NP_199353.1; NM_123908.2.
DR AlphaFoldDB; Q9FHJ6; -.
DR SMR; Q9FHJ6; -.
DR STRING; 3702.AT5G45400.1; -.
DR iPTMnet; Q9FHJ6; -.
DR PaxDb; Q9FHJ6; -.
DR PRIDE; Q9FHJ6; -.
DR ProteomicsDB; 236238; -.
DR EnsemblPlants; AT5G45400.1; AT5G45400.1; AT5G45400.
DR GeneID; 834576; -.
DR Gramene; AT5G45400.1; AT5G45400.1; AT5G45400.
DR KEGG; ath:AT5G45400; -.
DR Araport; AT5G45400; -.
DR TAIR; locus:2163553; AT5G45400.
DR eggNOG; KOG0851; Eukaryota.
DR HOGENOM; CLU_012393_3_0_1; -.
DR InParanoid; Q9FHJ6; -.
DR OMA; HEITLDH; -.
DR OrthoDB; 1189265at2759; -.
DR PhylomeDB; Q9FHJ6; -.
DR PRO; PR:Q9FHJ6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHJ6; baseline and differential.
DR Genevisible; Q9FHJ6; AT.
DR GO; GO:0005662; C:DNA replication factor A complex; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR CDD; cd04476; RPA1_DBD_C; 1.
DR CDD; cd04477; RPA1N; 1.
DR Gene3D; 2.40.50.140; -; 4.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR013955; Rep_factor-A_C.
DR InterPro; IPR007199; Rep_factor-A_N.
DR InterPro; IPR031657; REPA_OB_2.
DR InterPro; IPR004591; Rfa1.
DR PANTHER; PTHR23273; PTHR23273; 1.
DR Pfam; PF04057; Rep-A_N; 1.
DR Pfam; PF08646; Rep_fac-A_C; 1.
DR Pfam; PF16900; REPA_OB_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SUPFAM; SSF50249; SSF50249; 4.
DR TIGRFAMs; TIGR00617; rpa1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA replication; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..853
FT /note="Replication protein A 70 kDa DNA-binding subunit C"
FT /id="PRO_0000422617"
FT DNA_BIND 312..399
FT /note="OB"
FT ZN_FING 602..628
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT REGION 118..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 94394 MW; 673B141F64FAD835 CRC64;
MAVSLTEGVV MKMLNGEVTS ETDMMPVLQV TELKLIQSKL HQNQESSNRY KFLLSDGTDL
AAGMLNTSLN SLVNQGTIQL GSVIRLTHYI CNLIQTRRIV VIMQLEVIVE KCNIIGNPKE
PGHSSINPQR GGVNTQSNGG SEQQQARRSD VNGGRYGVSA NSPQPQVVHN SSDAGRYCVS
ANSPQPQVVH SSSDAGRYGV SANSPQRQVV HNSPDAGRYG QPQVSQRYGT GSGYPETSPS
TRPYVSSNAG YGGSRQDQPR APTATTAYSR PVQSAYQPQQ PPMYVNRGPV ARNEAPPRIN
PIAALNPYQG RWTIKVRVTS KADLRRFNNP RGEGKLFSFD LLDADGGEIR VTCFNDAVDQ
FFDKIVVGNV YLISRGNLKP AQKNFNHLPN DYEIHLDSAS TIQPCEDDGT IPRYHFHFRN
IGDIENMENN STTDVIGIVS SISPTVAIMR KNLTEVQKRS LQLKDMSGRS VEVTMWGNFC
NAEGQKLQNL CDSGVFPVLA LKAGRIGEFN GKQVSTIGAS QFFIEPDFPE ARELRQWYER
EGRNAHFTSI SREFSGVGRQ EVRKVIAQIK DEKLGTSEKP DWITVCATIS FMKVENFCYT
ACPIMNGDRP CSKKVTNNGD GTWRCEKCDK CVDECDYRYI LQIQLQDHTD LTWATAFQEA
GEEIMGMSAK DLYYVKYENQ DEEKFEDIIR SVAFTKYIFK LKIKEETYSD EQRVKATVVK
AEKLNYSSNT RFMLEAIDKL KIGDANSLPI KAESSNYRSD AFNSGVGTSG TRDTASVDAR
REFGLPAANQ VGQYGNQYSS DARSLGGFTS CNVCRSNSHV SANCPTLMSE PQGQYMGGTN
AGGGMPRQHV GSY
