ID   RFA1C_ORYSJ             Reviewed;         951 AA.
AC   Q65XV7; A0A0P0WH26;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Replication protein A 70 kDa DNA-binding subunit C;
DE            Short=OsRPA70c;
DE   AltName: Full=Replication factor A protein 1C;
DE   AltName: Full=Replication protein A 1C;
GN   Name=RPA1C; Synonyms=RPA70C;
GN   OrderedLocusNames=Os05g0111000, LOC_Os05g02040;
GN   ORFNames=OsJ_16860, P0016H04.11;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   INTERACTION WITH RPA2C.
RX   PubMed=16428324; DOI=10.1093/jb/mvj014;
RA   Ishibashi T., Kimura S., Sakaguchi K.;
RT   "A higher plant has three different types of RPA heterotrimeric complex.";
RL   J. Biochem. 139:99-104(2006).
CC   -!- FUNCTION: Component of the replication protein A complex (RPA) required
CC       for DNA recombination, repair and replication. The activity of RPA is
CC       mediated by single-stranded DNA binding and protein interactions.
CC       Probably involved in repair of double-strand DNA breaks (DSBs) induced
CC       by genotoxic stresses (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimer of RPA1, RPA2 and RPA3 (canonical replication
CC       protein A complex) (By similarity). Interacts with RPA2C. {ECO:0000250,
CC       ECO:0000269|PubMed:16428324}.
CC   -!- INTERACTION:
CC       Q65XV7; Q5Z8L1: RPA2C; NbExp=4; IntAct=EBI-849558, EBI-849544;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the replication factor A protein 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AC079356; AAU44205.1; -; Genomic_DNA.
DR   EMBL; AP008211; BAF16359.1; -; Genomic_DNA.
DR   EMBL; AP014961; BAS91923.1; -; Genomic_DNA.
DR   EMBL; CM000142; EEE62076.1; -; Genomic_DNA.
DR   EMBL; AK073598; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015638722.1; XM_015783236.1.
DR   AlphaFoldDB; Q65XV7; -.
DR   SMR; Q65XV7; -.
DR   IntAct; Q65XV7; 1.
DR   STRING; 4530.OS05T0111000-01; -.
DR   PaxDb; Q65XV7; -.
DR   PRIDE; Q65XV7; -.
DR   EnsemblPlants; Os05t0111000-01; Os05t0111000-01; Os05g0111000.
DR   GeneID; 4337594; -.
DR   Gramene; Os05t0111000-01; Os05t0111000-01; Os05g0111000.
DR   KEGG; osa:4337594; -.
DR   eggNOG; KOG0851; Eukaryota.
DR   eggNOG; KOG4400; Eukaryota.
DR   HOGENOM; CLU_012393_3_0_1; -.
DR   InParanoid; Q65XV7; -.
DR   OMA; DCPGQST; -.
DR   OrthoDB; 1189265at2759; -.
DR   PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR   PlantReactome; R-OSA-9675782; Maturation.
DR   PlantReactome; R-OSA-9675885; Lagging strand synthesis.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000007752; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   Genevisible; Q65XV7; OS.
DR   GO; GO:0005662; C:DNA replication factor A complex; IBA:GO_Central.
DR   GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR   CDD; cd04476; RPA1_DBD_C; 1.
DR   CDD; cd04477; RPA1N; 1.
DR   Gene3D; 2.40.50.140; -; 4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR013955; Rep_factor-A_C.
DR   InterPro; IPR007199; Rep_factor-A_N.
DR   InterPro; IPR031657; REPA_OB_2.
DR   InterPro; IPR004591; Rfa1.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR23273; PTHR23273; 1.
DR   Pfam; PF04057; Rep-A_N; 1.
DR   Pfam; PF08646; Rep_fac-A_C; 1.
DR   Pfam; PF16900; REPA_OB_2; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   Pfam; PF00098; zf-CCHC; 3.
DR   SMART; SM00343; ZnF_C2HC; 4.
DR   SUPFAM; SSF50249; SSF50249; 4.
DR   SUPFAM; SSF57756; SSF57756; 2.
DR   TIGRFAMs; TIGR00617; rpa1; 1.
DR   PROSITE; PS50158; ZF_CCHC; 3.
PE   1: Evidence at protein level;
KW   DNA damage; DNA recombination; DNA repair; DNA replication; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..951
FT                   /note="Replication protein A 70 kDa DNA-binding subunit C"
FT                   /id="PRO_0000422622"
FT   DNA_BIND        320..403
FT                   /note="OB"
FT   ZN_FING         612..639
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          139..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        37
FT                   /note="T -> A (in Ref. 6; AK073598)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   951 AA;  102951 MW;  FFD5D5B40CD01616 CRC64;
     MEPQLTPGAV QAIAEHPDGT GTIQPVLQVV DVRPVTTKNA PPTPKPAERF RMMLSDGVNT
     QQSMLATALN PLVKDATLRP GTVVQLTDFM CNTIQGKRII IVVKLDVLQN DCIVIGNPKH
     YEPKSLTKEQ DPNLQASVAQ TNNGTYSGGA SMLGPSVAPR AEQAASNSSY GGPYNSAQGM
     LGSSIGRTVE PGPANVSAVG SYGAISAQNT TNANMMQPTS QLNIMNANTM QPTSQLNTMN
     ANTMQPTSQL SSLNPNQNQR FAAPASGGVF GPPGNAYGQP SRPSYQQPPP VYMNRGPASR
     NDSATRIIPI TALNPYQPKW TIKARVTAKS DIRHWSNARS SGTVFSFDLL DAQGGEIRAQ
     CWKESADKFF GQIEVGRVYL ISRGSLKPAQ KKYNTLNHDY EITLDIGLST VEVCSDDDNS
     IPRLQYNFRQ ISELENMANE TIVDLLGVVT SVSPSATIMR KIGTETRKRS IQLKDLSGRS
     IEVTLWGNFC DAEGQQLQLQ CDSGSNPIIA FKGARVGDFN GKSVSTIGST QLIINPDFPE
     VERLRQWYMT EGKTAPCISL SREMLNMGRT DARKTIAQIK DENLGRLEKP DWITVKAAIS
     HVTTESFCYP ACPKLLPVGR QCNKKAINNG DGMWHCDRCD ESFQNPEYRY MLRFQIQDHT
     GSTYASAFDE AGEQIFGRKA GELFSIRNVD QDDAQFAEII EGVRWHLYLF KLKVKEETYN
     DEQSLKCTAV KVEKLDPSKE SNVLLGAIDN LLLDPKGQSD LAPNAGFTDP VGGHGAPTSS
     NAYAMNTGGV NQFGQQASIS AGMSTPLAAT RNLQTCSICG ANGHSAQICH VGADMDMQET
     SAGGSSMGNY NSIAGNGSSE CYKCKQPGHY ARDCPGQSTG GLECFKCKQP GHFSRDCPVQ
     STGGSECFKC KQPGHFARDC PGQSTGAQHQ TYGNNVAASR GYNRQSFVGG Y