RFAC_SALTY
ID RFAC_SALTY Reviewed; 317 AA.
AC P26469;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1;
DE EC=2.-.-.-;
GN Name=rfaC; Synonyms=waaC; OrderedLocusNames=STM3712;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1527014; DOI=10.1016/s0021-9258(19)37042-5;
RA Sirisena D.M., Brozek K.A., Maclachlan P.R., Sanderson K.E., Raetz C.R.H.;
RT "The rfaC gene of Salmonella typhimurium. Cloning, sequencing, and
RT enzymatic function in heptose transfer to lipopolysaccharide.";
RL J. Biol. Chem. 267:18874-18884(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-317.
RC STRAIN=LT2;
RX PubMed=1657881; DOI=10.1128/jb.173.22.7151-7163.1991;
RA Maclachlan P.R., Kadam S.K., Sanderson K.E.;
RT "Cloning, characterization, and DNA sequence of the rfaLK region for
RT lipopolysaccharide synthesis in Salmonella typhimurium LT2.";
RL J. Bacteriol. 173:7151-7163(1991).
CC -!- FUNCTION: Heptose transfer to the lipopolysaccharide core. It transfers
CC the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family. {ECO:0000305}.
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DR EMBL; M95927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE006468; AAL22571.1; -; Genomic_DNA.
DR EMBL; M73826; AAA27205.1; -; Genomic_DNA.
DR PIR; A44156; A44156.
DR RefSeq; NP_462612.1; NC_003197.2.
DR RefSeq; WP_001264604.1; NC_003197.2.
DR AlphaFoldDB; P26469; -.
DR SMR; P26469; -.
DR STRING; 99287.STM3712; -.
DR CAZy; GT9; Glycosyltransferase Family 9.
DR PaxDb; P26469; -.
DR EnsemblBacteria; AAL22571; AAL22571; STM3712.
DR GeneID; 1255236; -.
DR KEGG; stm:STM3712; -.
DR PATRIC; fig|99287.12.peg.3926; -.
DR HOGENOM; CLU_038371_6_0_6; -.
DR OMA; ITHLAWA; -.
DR PhylomeDB; P26469; -.
DR BioCyc; MetaCyc:STM3712-MON; -.
DR BioCyc; SENT99287:STM3712-MON; -.
DR UniPathway; UPA00958; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008713; F:ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IMP:CACAO.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR TIGRFAMs; TIGR02193; heptsyl_trn_I; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW Transferase.
FT CHAIN 1..317
FT /note="Lipopolysaccharide heptosyltransferase 1"
FT /id="PRO_0000207261"
SQ SEQUENCE 317 AA; 35172 MW; 21D03FA9D5574650 CRC64;
MRVLIVKTSS MGDVLHTLPA LTDAQQAIPG IQFDWAVEEG FAQIPSWHSA VDRVIPVAIR
RWRKAWFSAP IKAERTAFRR AVCANQYDAV IDAQGLVKSA ALVTRLAHGI KHGMDWSTAR
EPLASLFYNR KHHIAKQQHA VERTRELFAK SLGYDKPQSQ GDYAIAKHFL HCQQAVSDPY
AVFLHATTRD DKHWPEANWR ELIGLVGNTG LRIKLPWGAP HEEARAKRLA EGFDYVDVLP
RMSLEEVARV LAGAKFVVSV DTGLSHLTAA LDRPNITLYG PTDPGLIGGY GKNQMACCSP
EQNLANLDAT SVFGKIH