ID   RFAF_HAEIN              Reviewed;         346 AA.
AC   P45042;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=ADP-heptose--LPS heptosyltransferase 2;
DE            EC=2.-.-.-;
DE   AltName: Full=ADP-heptose--LPS heptosyltransferase II;
GN   Name=rfaF; OrderedLocusNames=HI_1105;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 9 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22760.1; -; Genomic_DNA.
DR   PIR; G64182; G64182.
DR   RefSeq; NP_439262.1; NC_000907.1.
DR   RefSeq; WP_005693429.1; NC_000907.1.
DR   AlphaFoldDB; P45042; -.
DR   SMR; P45042; -.
DR   STRING; 71421.HI_1105; -.
DR   CAZy; GT9; Glycosyltransferase Family 9.
DR   PRIDE; P45042; -.
DR   DNASU; 950079; -.
DR   EnsemblBacteria; AAC22760; AAC22760; HI_1105.
DR   KEGG; hin:HI_1105; -.
DR   PATRIC; fig|71421.8.peg.1153; -.
DR   eggNOG; COG0859; Bacteria.
DR   HOGENOM; CLU_038371_7_0_6; -.
DR   OMA; GSAKRWP; -.
DR   PhylomeDB; P45042; -.
DR   BioCyc; HINF71421:G1GJ1-1140-MON; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008713; F:ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IBA:GO_Central.
DR   CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR   InterPro; IPR002201; Glyco_trans_9.
DR   InterPro; IPR011910; RfaF.
DR   Pfam; PF01075; Glyco_transf_9; 1.
DR   TIGRFAMs; TIGR02195; heptsyl_trn_II; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN           1..346
FT                   /note="ADP-heptose--LPS heptosyltransferase 2"
FT                   /id="PRO_0000207263"
SQ   SEQUENCE   346 AA;  38847 MW;  14D0E11C6773FCA9 CRC64;
     MNILIIGPSW VGDMMMSHSL YQQLKIQYPN CNIDVMAPNW CKPLLARMPE VRKAIEMPLG
     HGAFELGTRY RLGKSLREQY DMAIVLPNSL KSAFIPFFAK IVHRRGWKGE SRYILLNDLR
     ANKKDYPMMV QRYVALAFEK DVIPKADDIP VLKPYLTVEP AQQAETLKKF EKQTALLGER
     PIIGFCPGAE FGPAKRWPHY HYAKLAEMLI TQGYAVALFG SAKDEPVGEE IRQALPEELR
     EFCVNLAGKT NLNEAVDLIA NCTAVVTNDS GLMHIAAAVN RPLIALYGPT SPQYTPPLSD
     KATIIRLIEG ELIKVRKGDK EGGYHQSLID ITPEMALEKL NELLAK