ID   RFAF_SALTY              Reviewed;         348 AA.
AC   P37421;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=ADP-heptose--LPS heptosyltransferase 2;
DE            EC=2.-.-.-;
DE   AltName: Full=ADP-heptose--LPS heptosyltransferase II;
GN   Name=rfaF; Synonyms=waaF; OrderedLocusNames=STM3711;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8157607; DOI=10.1128/jb.176.8.2379-2385.1994;
RA   Sirisena D.M., Maclachlan P.R., Liu S.L., Hessel A., Sanderson K.E.;
RT   "Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF
RT   gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella
RT   typhimurium.";
RL   J. Bacteriol. 176:2379-2385(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 9 family. {ECO:0000305}.
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DR   EMBL; U06472; AAA59065.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22570.1; -; Genomic_DNA.
DR   RefSeq; NP_462611.1; NC_003197.2.
DR   RefSeq; WP_000699190.1; NC_003197.2.
DR   AlphaFoldDB; P37421; -.
DR   SMR; P37421; -.
DR   STRING; 99287.STM3711; -.
DR   CAZy; GT9; Glycosyltransferase Family 9.
DR   PaxDb; P37421; -.
DR   DNASU; 1255235; -.
DR   EnsemblBacteria; AAL22570; AAL22570; STM3711.
DR   GeneID; 1255235; -.
DR   KEGG; stm:STM3711; -.
DR   PATRIC; fig|99287.12.peg.3925; -.
DR   HOGENOM; CLU_038371_7_0_6; -.
DR   PhylomeDB; P37421; -.
DR   BioCyc; MetaCyc:STM3711-MON; -.
DR   BioCyc; SENT99287:STM3711-MON; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008713; F:ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IMP:CACAO.
DR   CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR   InterPro; IPR002201; Glyco_trans_9.
DR   InterPro; IPR011910; RfaF.
DR   Pfam; PF01075; Glyco_transf_9; 1.
DR   TIGRFAMs; TIGR02195; heptsyl_trn_II; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN           1..348
FT                   /note="ADP-heptose--LPS heptosyltransferase 2"
FT                   /id="PRO_0000207264"
SQ   SEQUENCE   348 AA;  38985 MW;  744C4B3D135B7C3E CRC64;
     MKILVIGPSW VGDMMMSQSL YRTLKARYPQ AIIDVMAPAW CRPLLSRMPE VNEAIPMPLG
     HGALEIGERR RLGHSLREKR YDRAWVLPNS FKSALIPFFA NIPHRTGWRG EMRYGLLNDA
     RVLDKDAWPL MVERYVALAY DKGVMRAAKD LPQPLLWPQL QVSEGEKSLM CSDFSLSSER
     PLIGFCPGAE FGPAKRWPHY HYAELAKQLI NEGYQVVLFG SAKDHEAGNE ILAALNSEQQ
     AWCRNLAGET QLEQAVILIA ACKAIVTNDS GLMHVAAALD RPLVALYGPS SPDFTPPLSH
     KARVIRLITG YHKVRKGDTA QGYHQSLIDI TPQRVLEELH SLLSEEGV