RFAL1_HUMAN
ID RFAL1_HUMAN Reviewed; 287 AA.
AC F8VTS6;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Ret finger protein-like 4A-like protein 1;
GN Name=RFPL4AL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-256.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AC008749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CA454993; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59425.1; -.
DR RefSeq; NP_001264326.1; NM_001277397.1.
DR RefSeq; XP_011525561.1; XM_011527259.1.
DR AlphaFoldDB; F8VTS6; -.
DR SMR; F8VTS6; -.
DR iPTMnet; F8VTS6; -.
DR PhosphoSitePlus; F8VTS6; -.
DR BioMuta; RFPL4AL1; -.
DR MassIVE; F8VTS6; -.
DR MaxQB; F8VTS6; -.
DR PaxDb; F8VTS6; -.
DR PeptideAtlas; F8VTS6; -.
DR PRIDE; F8VTS6; -.
DR DNASU; 729974; -.
DR Ensembl; ENST00000341750.5; ENSP00000345151.5; ENSG00000229292.2.
DR GeneID; 729974; -.
DR KEGG; hsa:729974; -.
DR MANE-Select; ENST00000341750.5; ENSP00000345151.5; NM_001277397.2; NP_001264326.1.
DR UCSC; uc031rnc.2; human.
DR CTD; 729974; -.
DR GeneCards; RFPL4AL1; -.
DR HGNC; HGNC:45147; RFPL4AL1.
DR HPA; ENSG00000229292; Not detected.
DR neXtProt; NX_F8VTS6; -.
DR OpenTargets; ENSG00000229292; -.
DR VEuPathDB; HostDB:ENSG00000229292; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163220; -.
DR HOGENOM; CLU_013137_7_1_1; -.
DR InParanoid; F8VTS6; -.
DR OMA; WICINEW; -.
DR OrthoDB; 1139938at2759; -.
DR PhylomeDB; F8VTS6; -.
DR TreeFam; TF317532; -.
DR PathwayCommons; F8VTS6; -.
DR BioGRID-ORCS; 729974; 23 hits in 1014 CRISPR screens.
DR GenomeRNAi; 729974; -.
DR Pharos; F8VTS6; Tdark.
DR PRO; PR:F8VTS6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; F8VTS6; protein.
DR Bgee; ENSG00000229292; Expressed in right lobe of liver and 25 other tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd15821; SPRY_PRY_RFPL; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR022723; RDM_domain_RFPL.
DR InterPro; IPR038908; RFPL.
DR InterPro; IPR037960; SPRY/PRY_RFPL.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR25462:SF245; PTHR25462:SF245; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF11002; RDM; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..287
FT /note="Ret finger protein-like 4A-like protein 1"
FT /id="PRO_0000422543"
FT DOMAIN 78..276
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 11..53
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 43
FT /note="D -> N (in Ref. 2; CA454993)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="N -> Y (in Ref. 2; CA454993)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 32249 MW; 81E42D8758CE47A6 CRC64;
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIEL
SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHINT
FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSTASA PVSSEGK
