RFAL_SALTY
ID RFAL_SALTY Reviewed; 404 AA.
AC P26471;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=O-antigen ligase;
GN Name=rfaL; Synonyms=rfbT, waaL; OrderedLocusNames=STM3713;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1657881; DOI=10.1128/jb.173.22.7151-7163.1991;
RA Maclachlan P.R., Kadam S.K., Sanderson K.E.;
RT "Cloning, characterization, and DNA sequence of the rfaLK region for
RT lipopolysaccharide synthesis in Salmonella typhimurium LT2.";
RL J. Bacteriol. 173:7151-7163(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Adds the O-antigen on the glucose(II) group of LPS.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the O-antigen polymerase family. {ECO:0000305}.
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DR EMBL; M73826; AAA27206.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22572.1; -; Genomic_DNA.
DR PIR; B41317; B41317.
DR RefSeq; NP_462613.1; NC_003197.2.
DR RefSeq; WP_000958458.1; NC_003197.2.
DR AlphaFoldDB; P26471; -.
DR STRING; 99287.STM3713; -.
DR PaxDb; P26471; -.
DR EnsemblBacteria; AAL22572; AAL22572; STM3713.
DR GeneID; 1255237; -.
DR KEGG; stm:STM3713; -.
DR PATRIC; fig|99287.12.peg.3927; -.
DR HOGENOM; CLU_056701_0_0_6; -.
DR OMA; HISDSMV; -.
DR BioCyc; MetaCyc:STM3713-MON; -.
DR BioCyc; SENT99287:STM3713-MON; -.
DR UniPathway; UPA00958; -.
DR PHI-base; PHI:3726; -.
DR PHI-base; PHI:6587; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR007016; O-antigen_ligase-related.
DR Pfam; PF04932; Wzy_C; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ligase; Lipopolysaccharide biosynthesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..404
FT /note="O-antigen ligase"
FT /id="PRO_0000208067"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..244
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 404 AA; 46034 MW; 1B84F7B3C757D2AB CRC64;
MLTTSLTLNK EKWKPIWNKA LVFLFVATYF LDGITRYKHL IIILMVITAI YQVSRSPKSF
PPLFKNSVFY SVAVLSLILV YSILISPDMK ESFKEFENTV LEGFLLYTLL IPVLLKDETK
ETVAKIVLFS FLTSLGLRCL AESILYIEDY NKGIMPFISY AHRHMSDSMV FLFPALLNIW
LFRKNAIKLV FLVLSAIYLF FILGTLSRGA WLAVLIVGVL WAILNRQWKL IGVGAILLAI
IGALVITQHN NKPDPEHLLY KLQQTDSSYR YTNGTQGTAW ILIQENPIKG YGYGNDVYDG
VYNKRVVDYP TWTFKESIGP HNTILYIWFS AGILGLASLV YLYGAIIRET ASSTLRKVEI
SPYNAHLLLF LSFVGFYIVR GNFEQVDIAQ IGIITGFLLA LRNR
