ID   RFAY_SALTY              Reviewed;         232 AA.
AC   P26472; Q7BV71;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Lipopolysaccharide core heptose(II) kinase RfaY;
DE            EC=2.7.1.-;
GN   Name=rfaY; Synonyms=waaY; OrderedLocusNames=STM3716;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F98;
RX   PubMed=9573095; DOI=10.1128/iai.66.5.2099-2106.1998;
RA   Turner A.K., Lovell M.A., Hulme S.D., Zhang-Barber L., Barrow P.A.;
RT   "Identification of Salmonella typhimurium genes required for colonization
RT   of the chicken alimentary tract and for virulence in newly hatched
RT   chicks.";
RL   Infect. Immun. 66:2099-2106(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
RC   STRAIN=LT2;
RX   PubMed=9535865; DOI=10.1074/jbc.273.15.8849;
RA   Heinrichs D.E., Monteiro M.A., Perry M.B., Whitfield C.;
RT   "The assembly system for the lipopolysaccharide R2 core-type of Escherichia
RT   coli is a hybrid of those found in Escherichia coli K-12 and Salmonella
RT   enterica. Structure and function of the R2 WaaK and WaaL homologs.";
RL   J. Biol. Chem. 273:8849-8859(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-232.
RC   STRAIN=LT2;
RX   PubMed=1657881; DOI=10.1128/jb.173.22.7151-7163.1991;
RA   Maclachlan P.R., Kadam S.K., Sanderson K.E.;
RT   "Cloning, characterization, and DNA sequence of the rfaLK region for
RT   lipopolysaccharide synthesis in Salmonella typhimurium LT2.";
RL   J. Bacteriol. 173:7151-7163(1991).
CC   -!- FUNCTION: Catalyzes the phosphorylation of heptose(II) of the outer
CC       membrane lipopolysaccharide core. {ECO:0000250}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. RfaY/WaaY
CC       family. {ECO:0000305}.
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DR   EMBL; AF001397; AAB61279.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22575.1; -; Genomic_DNA.
DR   EMBL; AF026386; AAC16410.1; -; Genomic_DNA.
DR   EMBL; M73826; AAA27209.1; -; Genomic_DNA.
DR   PIR; E41317; E41317.
DR   RefSeq; NP_462616.1; NC_003197.2.
DR   RefSeq; WP_000582809.1; NC_003197.2.
DR   AlphaFoldDB; P26472; -.
DR   STRING; 99287.STM3716; -.
DR   PaxDb; P26472; -.
DR   PRIDE; P26472; -.
DR   EnsemblBacteria; AAL22575; AAL22575; STM3716.
DR   GeneID; 1255240; -.
DR   KEGG; stm:STM3716; -.
DR   PATRIC; fig|99287.12.peg.3930; -.
DR   HOGENOM; CLU_103657_0_0_6; -.
DR   OMA; ICKANDL; -.
DR   PhylomeDB; P26472; -.
DR   BioCyc; MetaCyc:STM3716-MON; -.
DR   BioCyc; SENT99287:STM3716-MON; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR009330; LipoPS_heptP_kinase.
DR   Pfam; PF06176; WaaY; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Lipopolysaccharide biosynthesis; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..232
FT                   /note="Lipopolysaccharide core heptose(II) kinase RfaY"
FT                   /id="PRO_0000097289"
SQ   SEQUENCE   232 AA;  27740 MW;  B890201198B6F65B CRC64;
     MIIEKKIKNY TVFVKKDGEK YIEIFKDFLS YNHQVIKVFR NIEDTKVVLI NTDYGKYILK
     VFSPKVKNTE RFFKSLVKGD YYEKLFHQTD RVRREGFAAL NDFYLLAEIK TLRYVKTYVM
     IIEYIEGIEL VDMPEISDEV RGKIKQSIYS LHQHGMVSGD PHKGNFILQG NEIRIIDLSG
     KRPSRQRKAK DRIDLERHYG IKNNVRDIGF YLLIYKKKLR NFLRRIKGKE KR