ID   RFBC_SALBO              Reviewed;         378 AA.
AC   P52642;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=UDP-N-acetylglucosamine 2-epimerase;
DE            EC=5.1.3.14;
DE   AltName: Full=UDP-GlcNAc-2-epimerase;
GN   Name=rfbC;
OS   Salmonella borreze.
OG   Plasmid pWQ799.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=55400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7545154; DOI=10.1128/jb.177.18.5247-5253.1995;
RA   Keenleyside W.J., Whitfield C.;
RT   "Lateral transfer of rfb genes: a mobilizable ColE1-type plasmid carries
RT   the rfbO:54 (O:54 antigen biosynthesis) gene cluster from Salmonella
RT   enterica serovar Borreze.";
RL   J. Bacteriol. 177:5247-5253(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
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DR   EMBL; L39794; AAC98403.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52642; -.
DR   SMR; P52642; -.
DR   BioCyc; MetaCyc:MON-21446; -.
DR   UniPathway; UPA00281; -.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR00236; wecB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lipopolysaccharide biosynthesis; Plasmid.
FT   CHAIN           1..378
FT                   /note="UDP-N-acetylglucosamine 2-epimerase"
FT                   /id="PRO_0000208526"
FT   ACT_SITE        214
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   378 AA;  42495 MW;  0280B9AA36CC778C CRC64;
     MSKVLFVFGT RPEAIKMAPL VIEFKNNPAI EVKVCVTGQH REMLDQVLDF FEIEPDYDLN
     IMKQKQSLGS ITCSILTRLD EILASFMPAH IFVHGDTTTT FAASLAAFYQ NIKVWHIEAG
     LRTWNMNSPF PEEGNRQLTS KLAFFHAAPT LQAKDNLLRE SVKEKNIIVT GNTVIDALLI
     GIKKITGSTG DVREIISLKN KLNLDKKIIL VTLHRRENQG ELLRTICDDI KQLALEHDDI
     EIVFPVHMSP RIREVVNEKL SGVVNIKLVE PLAYPGFIWL MNNAHFILSD SGGVQEEAPS
     LQKPVLVARD TTERPEVIEN GAAMLVDPRI PNNIYSSCKK LLSDERLYEK MSQAGNPFGD
     GKASKKILDY FVSLEDIK