ID   RFBF_SHIFL              Reviewed;         296 AA.
AC   P37782;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2003, sequence version 2.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=dTDP-rhamnosyl transferase RfbF;
DE            EC=2.4.-.-;
GN   Name=rfbF; OrderedLocusNames=SF2099, S2221;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PE577 / Serotype 2a;
RX   PubMed=7507920; DOI=10.1128/jb.176.3.733-747.1994;
RA   Morona R., Mavris M., Fallarino A., Manning P.A.;
RT   "Characterization of the rfc region of Shigella flexneri.";
RL   J. Bacteriol. 176:733-747(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR   EMBL; X71970; CAA50772.1; -; Genomic_DNA.
DR   EMBL; AE005674; AAN43638.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17467.1; -; Genomic_DNA.
DR   PIR; A36966; A36966.
DR   RefSeq; NP_707931.1; NC_004337.2.
DR   AlphaFoldDB; P37782; -.
DR   SMR; P37782; -.
DR   STRING; 198214.SF2099; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   EnsemblBacteria; AAN43638; AAN43638; SF2099.
DR   EnsemblBacteria; AAP17467; AAP17467; S2221.
DR   GeneID; 1026771; -.
DR   KEGG; sfl:SF2099; -.
DR   KEGG; sfx:S2221; -.
DR   PATRIC; fig|198214.7.peg.2507; -.
DR   HOGENOM; CLU_023845_9_1_6; -.
DR   OrthoDB; 957193at2; -.
DR   UniPathway; UPA00030; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR006446; RhaTrfase.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01556; rhamnosyltran; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Reference proteome;
KW   Transferase.
FT   CHAIN           1..296
FT                   /note="dTDP-rhamnosyl transferase RfbF"
FT                   /id="PRO_0000059214"
FT   CONFLICT        203
FT                   /note="K -> E (in Ref. 1 and 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   296 AA;  33850 MW;  E2A75105EF86AE30 CRC64;
     MNSNIYAVIV TYNPELKNLN ALITELKEQN CYVVVVDNRT NFTLKDKLAD IEKVHLICLG
     RNEGIAKAQN IGIRYSLEKG AEKIIFFDQD SRIRNEFIKK LSCYMDNENA KIAGPVFIDR
     DKSHYYPICN IKKNGLREKI HVTEGQTPFK SSVTISSGTM VSKEVFEIVG MMDEELFIDY
     VDTEWCLRCL NYGILVHIIP DIKMVHAIGD KSVKICGINI PIHSPVRRYY RVRNAFLLLR
     KNHVPLLLSI REVVFSLIHT TLIIATQKNK IEYMKKHILA TLDGIRGITG GGRYNA