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RFBG_SALTY
ID   RFBG_SALTY              Reviewed;         359 AA.
AC   P26397;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=CDP-glucose 4,6-dehydratase;
DE            EC=4.2.1.45;
GN   Name=rfbG; OrderedLocusNames=STM2091;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1710759; DOI=10.1111/j.1365-2958.1991.tb00741.x;
RA   Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R.;
RT   "Structure and sequence of the rfb (O antigen) gene cluster of Salmonella
RT   serovar typhimurium (strain LT2).";
RL   Mol. Microbiol. 5:695-713(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O;
CC         Xref=Rhea:RHEA:17153, ChEBI:CHEBI:15377, ChEBI:CHEBI:58166,
CC         ChEBI:CHEBI:58660; EC=4.2.1.45;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; CDP-3,6-dideoxy-D-mannose
CC       biosynthesis; CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-
CC       phosphate: step 2/5.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; X56793; CAA40121.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20995.1; -; Genomic_DNA.
DR   PIR; S15305; S15305.
DR   RefSeq; NP_461036.1; NC_003197.2.
DR   RefSeq; WP_000565905.1; NC_003197.2.
DR   PDB; 1WVG; X-ray; 1.80 A; A/B=2-359.
DR   PDBsum; 1WVG; -.
DR   AlphaFoldDB; P26397; -.
DR   SMR; P26397; -.
DR   STRING; 99287.STM2091; -.
DR   DrugBank; DB02059; Adenosine-5-Diphosphoribose.
DR   DrugBank; DB03069; Cytidine-5'-diphospho-beta-D-xylose.
DR   PaxDb; P26397; -.
DR   EnsemblBacteria; AAL20995; AAL20995; STM2091.
DR   GeneID; 1253612; -.
DR   KEGG; stm:STM2091; -.
DR   PATRIC; fig|99287.12.peg.2213; -.
DR   HOGENOM; CLU_007383_1_7_6; -.
DR   OMA; CYENREW; -.
DR   PhylomeDB; P26397; -.
DR   BioCyc; SENT99287:STM2091-MON; -.
DR   UniPathway; UPA00055; UER00512.
DR   UniPathway; UPA00281; -.
DR   EvolutionaryTrace; P26397; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0047733; F:CDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05252; CDP_GD_SDR_e; 1.
DR   InterPro; IPR013445; CDP_4_6_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR02622; CDP_4_6_dhtase; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lipopolysaccharide biosynthesis; Lyase; NAD;
KW   Reference proteome.
FT   CHAIN           1..359
FT                   /note="CDP-glucose 4,6-dehydratase"
FT                   /id="PRO_0000097294"
FT   HELIX           4..7
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          11..15
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   TURN            16..18
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           20..31
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          35..42
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          44..47
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           49..52
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           55..57
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          59..63
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           69..79
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          82..86
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           93..98
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           100..121
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          126..130
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           133..135
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          141..143
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           156..175
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           178..180
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           181..184
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          187..193
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          195..197
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           207..216
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          221..224
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          232..234
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           236..251
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           253..256
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          258..262
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           266..268
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           272..283
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   STRAND          289..291
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           308..313
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           322..337
FT                   /evidence="ECO:0007829|PDB:1WVG"
FT   HELIX           342..355
FT                   /evidence="ECO:0007829|PDB:1WVG"
SQ   SEQUENCE   359 AA;  41022 MW;  D6EB7B3D36B2F9FB CRC64;
     MIDKNFWQGK RVFVTGHTGF KGSWLSLWLT EMGAIVKGYA LDAPTVPSLF EIVRLNDLME
     SHIGDIRDFE KLRNSIAEFK PEIVFHMAAQ PLVRLSYEQP IETYSTNVMG TVHLLETVKQ
     VGNIKAVVNI TSDKCYDNRE WVWGYRENEP MGGYDPYSNS KGCAELVASA FRNSFFNPAN
     YEQHGVGLAS VRAGNVIGGG DWAKDRLIPD ILRSFENNQQ VIIRNPYSIR PWQHVLEPLS
     GYIVVAQRLY TEGAKFSEGW NFGPRDEDAK TVEFIVDKMV TLWGDDASWL LDGENHPHEA
     HYLKLDCSKA NMQLGWHPRW GLTETLGRIV KWHKAWIRGE DMLICSKREI SDYMSATTR
 
 
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