RFC1_DICDI
ID RFC1_DICDI Reviewed; 1401 AA.
AC Q54MH9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Probable replication factor C subunit 1;
DE AltName: Full=Activator 1 subunit 1;
GN Name=rfc1; ORFNames=DDB_G0285961;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC delta and epsilon requires the action of the accessory proteins
CC proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1
CC binds to the primer-template junction (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000082; EAL64515.1; -; Genomic_DNA.
DR RefSeq; XP_638011.1; XM_632919.1.
DR AlphaFoldDB; Q54MH9; -.
DR SMR; Q54MH9; -.
DR STRING; 44689.DDB0232230; -.
DR PaxDb; Q54MH9; -.
DR PRIDE; Q54MH9; -.
DR EnsemblProtists; EAL64515; EAL64515; DDB_G0285961.
DR GeneID; 8625362; -.
DR KEGG; ddi:DDB_G0285961; -.
DR dictyBase; DDB_G0285961; rfc1.
DR eggNOG; KOG1968; Eukaryota.
DR HOGENOM; CLU_254323_0_0_1; -.
DR InParanoid; Q54MH9; -.
DR OMA; RLYYVPM; -.
DR PhylomeDB; Q54MH9; -.
DR Reactome; R-DDI-5656169; Termination of translesion DNA synthesis.
DR Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-DDI-69091; Polymerase switching.
DR PRO; PR:Q54MH9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005663; C:DNA replication factor C complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003689; F:DNA clamp loader activity; ISS:dictyBase.
DR GO; GO:0006272; P:leading strand elongation; ISS:dictyBase.
DR GO; GO:0006298; P:mismatch repair; ISS:dictyBase.
DR Gene3D; 3.40.50.10190; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Activator; ATP-binding; DNA replication; DNA-binding; Nucleotide-binding;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1401
FT /note="Probable replication factor C subunit 1"
FT /id="PRO_0000330464"
FT DOMAIN 637..727
FT /note="BRCT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT REGION 1..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 898..905
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1401 AA; 153582 MW; 1F4328D06524FFD9 CRC64;
MAKKANKEQS PKKTSPTSSQ GSTATKKKTK TSEPAGTDIR NFFAVIKPST SGENVKNDLF
SKAKEDSNKE FSLSDKENDD VKIISNKKDT TNNDKKKPSE NKSPKKKEPS KSIDLTSDED
KSSSEEDKKK PSSSSSKKKP SSSSSSLPNK KKSTLKRLKK KRDDSSSSSS SSESDFDSGS
DLDIESIDQK PKTITKKKNL KRKSKPDSSS SSEDETKHQK DKKIKLKTPE KKIEEPEKKV
EIPSSTSSIS SSQKKIVYSF EDSEDSDADK PIPPSKKPSA VVVNAPSTKT FEKKKENTDI
PPSPSKTKET TSTTTDTKPI KSPSKSNKST TPTTTTPITT EKKKIAQLEF ESPIVSITAI
DTEKKKDGNK DNKNKEKDKD SSPFDEMEIE ESKSKTIMPN NNNNNKSKES SSSTTNSKNN
TSMNDDLIFD DFAFSPIKSG SNKTTPSKST SSPSKETTPI KTRSKTVESK FDDDSIFDSP
DKKTTTTTAS NTKTKTPPSK KDKFNHDIIF EESDTPLNRA IEDSIVKRSL SGLNNIDKDS
KTTTTTTTEK KQKLKSDPFD TETEEETEDE GDEPLYKQQS SSFGSGSINP TATPTTPTKK
PAATSTNATP TKKPNPFMYM NGRPTPPNKG SKPRPQGKEN CLRGKVFLVS GVMDCFERDE
MHDIIKRWGG KVAKSAVKLL NYLVSGKDVG EKKLEGAKKV GAKIITEDEF LEMINKTLPK
PVSTTETTHI SLPTPTPTPT PTPASSSSSS TTTTTTTTTT TTNSTGIKGP SLPVRSGSGG
SSTGIKGPSL PVRSGSGGTT SSSPPLTFTS SPPTSTTTAT TTTTSSPPIS MASVIVPKSI
STIPKGHDIL WVEKYRPKVI EDIVGNPGIF QEFGKWLDQW NSTAPRDASK KNAVLLSGPP
GIGKTSAALL ICKQKGFEAI ELNASDARSK SEIKRLLSGV SDNQNITKFF GTTNQDTGKD
VQANKKIKTA IILDEIDGSS GNSDRGGIAE IIGLIKKSKM PFICLCNDYY SSKVTSLRNH
CMDLKLRKPT LNQVSSRLLA IAKHEGMKVS SYMIEKVYTS SHSDIRQSIN TLQMMSRSKR
DYNNDNVTQS LQEKDFDISP FTAAELILRE DNSNINKKLD YFFSDFSLVP LIIQENYLKT
RPYGGGSQSK YNDCELISMA ADALSDSDQF GRAIGKEMAW NLLPTYGVTS CIIPSGYIRG
SPPMPLSFPS YLGKYSNASK QQRFVRELQL HMRSTSNTFV NRDETRLYYV PMLKHHLIQP
LVQDDNDGIE NVINVMDEYG LTEDDRNNII ELSTWGKEDP LKDVKTQVKS AFTRKFRSTS
HAIYDVSLLS SKGSGGGGTN IAEGYEEVEG ESQNQIEEED EETEEKDSLP NLVKKSSVKS
KSDTKPKSTK SKSTTTKSKK K
