RFC1_ORYSJ
ID RFC1_ORYSJ Reviewed; 1021 AA.
AC Q2R2B4; A0A0P0Y3I3; Q84N08;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Replication factor C subunit 1;
DE Short=OsRFC1;
DE AltName: Full=Activator 1 large subunit;
DE AltName: Full=Activator 1 subunit 1;
GN Name=RFC1; OrderedLocusNames=Os11g0572100, LOC_Os11g36390;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, AND GENE FAMILY.
RC STRAIN=cv. Nipponbare;
RX PubMed=14756303; DOI=10.1023/b:plan.0000009258.04711.62;
RA Furukawa T., Ishibashi T., Kimura S., Tanaka H., Hashimoto J.,
RA Sakaguchi K.;
RT "Characterization of all the subunits of replication factor C from a higher
RT plant, rice (Oryza sativa L.), and their relation to development.";
RL Plant Mol. Biol. 53:15-25(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: May be involved in DNA replication and thus regulate cell
CC proliferation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC form a complex with RFC1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, shoot apical meristem
CC (SAM), flag leaves and panicles. {ECO:0000269|PubMed:14756303}.
CC -!- INDUCTION: Down-regulated by sucrose starvation.
CC {ECO:0000269|PubMed:14756303}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000305}.
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DR EMBL; AB109200; BAC76085.1; -; mRNA.
DR EMBL; DP000010; ABA94349.2; -; Genomic_DNA.
DR EMBL; AP008217; BAF28486.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT14532.1; -; Genomic_DNA.
DR EMBL; AK070564; BAG92033.1; -; mRNA.
DR RefSeq; XP_015617630.1; XM_015762144.1.
DR AlphaFoldDB; Q2R2B4; -.
DR SMR; Q2R2B4; -.
DR STRING; 4530.OS11T0572100-01; -.
DR iPTMnet; Q2R2B4; -.
DR PaxDb; Q2R2B4; -.
DR PRIDE; Q2R2B4; -.
DR EnsemblPlants; Os11t0572100-01; Os11t0572100-01; Os11g0572100.
DR EnsemblPlants; Os11t0572100-02; Os11t0572100-02; Os11g0572100.
DR GeneID; 4350754; -.
DR Gramene; Os11t0572100-01; Os11t0572100-01; Os11g0572100.
DR Gramene; Os11t0572100-02; Os11t0572100-02; Os11g0572100.
DR KEGG; osa:4350754; -.
DR eggNOG; KOG1968; Eukaryota.
DR HOGENOM; CLU_003574_4_0_1; -.
DR InParanoid; Q2R2B4; -.
DR OMA; PVGAENC; -.
DR OrthoDB; 307415at2759; -.
DR PlantReactome; R-OSA-9675815; Leading strand synthesis.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR ExpressionAtlas; Q2R2B4; baseline and differential.
DR Genevisible; Q2R2B4; OS.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0051570; P:regulation of histone H3-K9 methylation; IEA:EnsemblPlants.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:EnsemblPlants.
DR Gene3D; 3.40.50.10190; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..1021
FT /note="Replication factor C subunit 1"
FT /id="PRO_0000422634"
FT DOMAIN 257..347
FT /note="BRCT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT REGION 1..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..957
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 465..472
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 435
FT /note="R -> K (in Ref. 1; BAC76085)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1021 AA; 110900 MW; B674A64AFEF9D6B1 CRC64;
MSSDIRKWFM KAQDKNGGAA KPAGTTALAK KPVLSIPEKP SAAPSMAACD QDCSARRKTS
KYFASKTEKE EDTSAGKGTG RGLPKRKLQK VSDELEDDMK PLPAKEVHKE EEDDDDDDFV
APSKRKTPVK PPPSKKLKGA STAEAHGKTG LDDDNEDKMD EDAKTPSKAS GSGRGRGRGR
GRGGRGAGAA HGKTIGLDDD GEEDKMDEDA KTPSKAAGRG RGGASGGRGR GGGGRGFMNF
GERKDPPHKG EKEVPEGAPD CLTGLTFVIS GTLDSLEREE ATDLIKRYGG RVTGSISKKT
NYLLADEDVG GVKSNKAKEL GVPFLTEDGL FDMIRKSKPA KATVAKHQSD KNSEKQQKSP
MKSSPVKVER RDGNQITTGK NISPKSNKGS ASIDNQKVNI VDRGSLQWTE KYRPKVPNDI
VGNQSMVKQL HDWLRSWEDQ FLHSGQKGKG KKQADSGAKK AVLLSGPPGI GKTTTAKVVS
QMLGLQAIEV NASDSRGKAD SKIEKGVGGS TSNSIKELIS NATLNYSNNR LKRPKAVLVM
DEVDGMSAGD RGGVADLIAS IKMSKIPIIC ICNDRYSQKL KSLVNYCLLL NFRKPTKQQM
GKRLMEIAKK EGLQAQENAM EELAERVHGD IRMALNHLQY MSLSQSVVKY DDIRQRLNSS
TKDEDISPFT AVDKLFGFNG GRLRMDERID LSMSDPDLVP LIIQENYINY RPITVGKDDS
GVKRMNFLAR AAESIADADI VNVQIRRYRQ WQLSQAACLS SSIVPAALMH GNREILEAGE
RNFNRFGGWL GKYSTTNKNI RLLEDAHSHI LASQQANLDR ESLRLDYLTL LLRQLTDPLK
TMPKDEAVQK VVEFMDTYSL SQEDFDTIVE LSKFKGHPNP MDGIQPAVKS ALTKAYKQGS
SSRVVRAADL VNIPGMKKPL KKRVAAILEP VGESLPEENG VASSEGDEED SSDAENNDEL
VPGDTKPKLD LQSDKKKGIQ VQLDLKSNGN GLNSKKMPAG RSKASGSAGK AAGGSGGKRK
R
