ID   RFC2_DICDI              Reviewed;         338 AA.
AC   Q54E21;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Probable replication factor C subunit 2;
DE   AltName: Full=Activator 1 subunit 2;
GN   Name=rfc2; ORFNames=DDB_G0291868;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC       delta and epsilon requires the action of the accessory proteins PCNA
CC       and activator 1. {ECO:0000250}.
CC   -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC       (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000186; EAL61464.1; -; Genomic_DNA.
DR   RefSeq; XP_629875.1; XM_629873.1.
DR   AlphaFoldDB; Q54E21; -.
DR   SMR; Q54E21; -.
DR   STRING; 44689.DDB0232231; -.
DR   PaxDb; Q54E21; -.
DR   EnsemblProtists; EAL61464; EAL61464; DDB_G0291868.
DR   GeneID; 8628373; -.
DR   KEGG; ddi:DDB_G0291868; -.
DR   dictyBase; DDB_G0291868; rfc2.
DR   eggNOG; KOG0991; Eukaryota.
DR   HOGENOM; CLU_042324_0_1_1; -.
DR   InParanoid; Q54E21; -.
DR   OMA; SCNYSSQ; -.
DR   PhylomeDB; Q54E21; -.
DR   Reactome; R-DDI-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-69091; Polymerase switching.
DR   PRO; PR:Q54E21; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005663; C:DNA replication factor C complex; ISS:dictyBase.
DR   GO; GO:0031391; C:Elg1 RFC-like complex; ISS:dictyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; ISS:dictyBase.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; ISS:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..338
FT                   /note="Probable replication factor C subunit 2"
FT                   /id="PRO_0000330463"
FT   BINDING         60..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   338 AA;  37453 MW;  678803D951A8C89D CRC64;
     MTTTTTTTTN TNTTNLDPLL PWVEKYRPIL IKDIVGNEET VSRLESISKD GNLPNIIISG
     PPGTGKTSSI LCLARALLGA NYKEAVYELN ASDDRTLDVV RDKIKSFAMK KVTLPAGRHK
     IIILDEVDSM TSGAQQALRR IMEIYSGTTR FAFACNQSTK IIEPIQSRCA VLRFTRLSDS
     QILTRLREVV QIEKVPYTDD GLAAIIFTAE GDMRQALNNL QATHSGFGLI NAENVTKVCD
     QPHPLIIKQI IALCAKSDFK EAYPFLKKLW DDGYSSIDII SALFSITKSS NNIPEYQKLE
     FLKEIGFCNL RATTGVNTLV QLTGLLSKLC LVSIKMKN