ID   RFC2_ORYSJ              Reviewed;         339 AA.
AC   Q9FXM3; A0A0P0Y7I8; Q0IPQ0;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Replication factor C subunit 2;
DE            Short=OsRFC2;
DE   AltName: Full=Activator 1 subunit 2;
GN   Name=RFC2; OrderedLocusNames=Os12g0176500, LOC_Os12g07720;
GN   ORFNames=OsJ_35406;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, AND GENE FAMILY.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=14756303; DOI=10.1023/b:plan.0000009258.04711.62;
RA   Furukawa T., Ishibashi T., Kimura S., Tanaka H., Hashimoto J.,
RA   Sakaguchi K.;
RT   "Characterization of all the subunits of replication factor C from a higher
RT   plant, rice (Oryza sativa L.), and their relation to development.";
RL   Plant Mol. Biol. 53:15-25(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: May be involved in DNA replication and thus regulate cell
CC       proliferation. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC       form a complex with RFC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, shoot apical meristem
CC       (SAM), flag leaves and panicles. {ECO:0000269|PubMed:14756303}.
CC   -!- INDUCTION: Down-regulated by sucrose starvation.
CC       {ECO:0000269|PubMed:14756303}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AB045677; BAB16441.1; -; mRNA.
DR   EMBL; DP000011; ABA96606.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF29315.2; -; Genomic_DNA.
DR   EMBL; AP014968; BAT16111.1; -; Genomic_DNA.
DR   EMBL; CM000149; EAZ19823.1; -; Genomic_DNA.
DR   EMBL; AK103718; BAG96226.1; -; mRNA.
DR   RefSeq; XP_015618344.1; XM_015762858.1.
DR   AlphaFoldDB; Q9FXM3; -.
DR   SMR; Q9FXM3; -.
DR   STRING; 4530.OS12T0176500-01; -.
DR   PaxDb; Q9FXM3; -.
DR   PRIDE; Q9FXM3; -.
DR   EnsemblPlants; Os12t0176500-01; Os12t0176500-01; Os12g0176500.
DR   GeneID; 4351654; -.
DR   Gramene; Os12t0176500-01; Os12t0176500-01; Os12g0176500.
DR   KEGG; osa:4351654; -.
DR   eggNOG; KOG0989; Eukaryota.
DR   HOGENOM; CLU_042324_1_0_1; -.
DR   InParanoid; Q9FXM3; -.
DR   OMA; KIVMVFS; -.
DR   OrthoDB; 1071197at2759; -.
DR   PlantReactome; R-OSA-9675815; Leading strand synthesis.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   Genevisible; Q9FXM3; OS.
DR   GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..339
FT                   /note="Replication factor C subunit 2"
FT                   /id="PRO_0000422635"
FT   BINDING         48..55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  37426 MW;  C20AED55D78C1E63 CRC64;
     MAPLVPSSQP WVEKYRPRQV KDVAHQEEVV RVLTTTLQTA DLPHMLFYGP PGTGKTTTAL
     AIAYQLYGPE LYKSRVLELN ASDDRGINVV RTKIKDFAAV AVGSARKGGY PCPPYKIIIL
     DEADSMTEDA QNALRRTMET YSKVTRFFFI CNYISRIIEP LASRCAKFRF KPLSEEVMSN
     RILHICNEEG LSLDAQALAT LSTISNGDLR RAITYLQSAA RLFGSSISST DLISVSGAIP
     EDVVKSLLAS CKSGEFDVAN KEVNNIIADG YPVSQLISQF LDVIVNADDI PDEQKARICK
     KLGEADKCLV DGADEYLQLL DVASETIRAL FDMPQTLVF