RFC3_ARATH
ID RFC3_ARATH Reviewed; 354 AA.
AC Q8VXX4;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Replication factor C subunit 3;
DE Short=AtRFC3;
DE AltName: Full=Activator 1 subunit 3;
DE AltName: Full=Protein EMBRYO DEFECTIVE 161;
DE AltName: Full=Protein EMBRYO DEFECTIVE 251;
DE AltName: Full=Protein EMBRYO DEFECTIVE 2775;
GN Name=RFC3; Synonyms=EMB161, EMB251, EMB2775, RFC5;
GN OrderedLocusNames=At5g27740; ORFNames=T1G16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: May be involved in DNA replication and thus regulate cell
CC proliferation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC form a complex with RFC1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC {ECO:0000305}.
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DR EMBL; AC069556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93720.1; -; Genomic_DNA.
DR EMBL; AY074381; AAL67077.1; -; mRNA.
DR EMBL; AY091236; AAM14175.1; -; mRNA.
DR RefSeq; NP_198126.1; NM_122656.5.
DR AlphaFoldDB; Q8VXX4; -.
DR SMR; Q8VXX4; -.
DR BioGRID; 18110; 7.
DR STRING; 3702.AT5G27740.1; -.
DR PaxDb; Q8VXX4; -.
DR PRIDE; Q8VXX4; -.
DR ProteomicsDB; 236230; -.
DR EnsemblPlants; AT5G27740.1; AT5G27740.1; AT5G27740.
DR GeneID; 832836; -.
DR Gramene; AT5G27740.1; AT5G27740.1; AT5G27740.
DR KEGG; ath:AT5G27740; -.
DR Araport; AT5G27740; -.
DR TAIR; locus:2180315; AT5G27740.
DR eggNOG; KOG2035; Eukaryota.
DR HOGENOM; CLU_042324_5_0_1; -.
DR InParanoid; Q8VXX4; -.
DR OMA; LMCEACK; -.
DR OrthoDB; 1071197at2759; -.
DR PhylomeDB; Q8VXX4; -.
DR PRO; PR:Q8VXX4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8VXX4; baseline and differential.
DR Genevisible; Q8VXX4; AT.
DR GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; DNA replication; DNA-binding; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..354
FT /note="Replication factor C subunit 3"
FT /id="PRO_0000422631"
FT BINDING 41..48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 354 AA; 40600 MW; 26FFFA83ABEC43BF CRC64;
MLWVDKYRPK SLDKVIVHED IAQKLKKLVS EQDCPHLLFY GPSGSGKKTL IMALLKQIYG
ASAEKVKVEN RAWKVDAGSR TIDLELTTLS STNHVELTPS DAGFQDRYIV QEIIKEMAKN
RPIDTKGKKG YKVLVLNEVD KLSREAQHSL RRTMEKYSSS CRLILCCNSS SKVTEAIKSR
CLNVRINAPS QEEIVKVLEF VAKKESLQLP QGFAARIAEK SNRSLRRAIL SLETCRVQNY
PFTGNQVISP MDWEEYVAEI ATDMMKEQSP KKLFQVRGKV YELLVNCIPP EVILKRLLHE
LLKKLDSELK LEVCHWAAYY EHRMRLGQKA IFHIEAFVAK FMSIYKNFLI STFG
