RFC4_ARATH
ID RFC4_ARATH Reviewed; 339 AA.
AC Q93ZX1; Q9XI09;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Replication factor C subunit 4;
DE Short=AtRFC4;
DE AltName: Full=Activator 1 subunit 4;
DE AltName: Full=Protein EMBRYO DEFECTIVE 1968;
GN Name=RFC4; Synonyms=EMB1968; OrderedLocusNames=At1g21690; ORFNames=F8K7.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in DNA replication and thus regulate cell
CC proliferation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC form a complex with RFC1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q93ZX1; Q9ZR37: DSPTP1; NbExp=3; IntAct=EBI-4470690, EBI-25512239;
CC Q93ZX1; P93002: NPR1; NbExp=3; IntAct=EBI-4470690, EBI-1392127;
CC Q93ZX1; Q8L746: NPR3; NbExp=3; IntAct=EBI-4470690, EBI-4441365;
CC Q93ZX1; Q9LVQ0: PME31; NbExp=4; IntAct=EBI-4470690, EBI-4466887;
CC Q93ZX1; Q38845: PP2AA1; NbExp=3; IntAct=EBI-4470690, EBI-1645478;
CC Q93ZX1; Q9CAQ8: RFC5; NbExp=7; IntAct=EBI-4470690, EBI-25513346;
CC Q93ZX1; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-4470690, EBI-15192297;
CC Q93ZX1; Q5CCK4: VAL2; NbExp=3; IntAct=EBI-4470690, EBI-15193683;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q93ZX1-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD41422.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007727; AAD41422.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30139.1; -; Genomic_DNA.
DR EMBL; AY056210; AAL07059.1; -; mRNA.
DR EMBL; AY062637; AAL32715.1; -; mRNA.
DR EMBL; BT010368; AAQ56811.1; -; mRNA.
DR EMBL; AY084702; AAM61276.1; -; mRNA.
DR PIR; B86350; B86350.
DR RefSeq; NP_564148.1; NM_102018.4. [Q93ZX1-1]
DR AlphaFoldDB; Q93ZX1; -.
DR SMR; Q93ZX1; -.
DR BioGRID; 24010; 9.
DR IntAct; Q93ZX1; 8.
DR STRING; 3702.AT1G21690.3; -.
DR PaxDb; Q93ZX1; -.
DR EnsemblPlants; AT1G21690.1; AT1G21690.1; AT1G21690. [Q93ZX1-1]
DR GeneID; 838771; -.
DR Gramene; AT1G21690.1; AT1G21690.1; AT1G21690. [Q93ZX1-1]
DR KEGG; ath:AT1G21690; -.
DR Araport; AT1G21690; -.
DR eggNOG; KOG0989; Eukaryota.
DR OMA; KIVMVFS; -.
DR PhylomeDB; Q93ZX1; -.
DR PRO; PR:Q93ZX1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q93ZX1; baseline and differential.
DR Genevisible; Q93ZX1; AT.
DR GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013748; Rep_factorC_C.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF08542; Rep_fac_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; DNA replication; DNA-binding;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..339
FT /note="Replication factor C subunit 4"
FT /id="PRO_0000422632"
FT BINDING 49..56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 339 AA; 37508 MW; 2895170ECBE2C322 CRC64;
MAPVLQSSQP WVEKYRPKQV KDVAHQEEVV RVLTNTLQTA DCPHMLFYGP PGTGKTTTAL
AIAHQLFGPE LYKSRVLELN ASDDRGINVV RTKIKDFAAV AVGSNHRQSG YPCPSFKIII
LDEADSMTED AQNALRRTME TYSKVTRFFF ICNYISRIIE PLASRCAKFR FKPLSEEVMS
NRILHICNEE GLSLDGEALS TLSSISQGDL RRAITYLQSA TRLFGSTITS TDLLNVSGVV
PLEVVNKLFT ACKSGDFDIA NKEVDNIVAE GYPASQIINQ LFDIVAEADS DITDMQKAKI
CKCLAETDKR LVDGADEYLQ LLDVASSTIC ALSEMAQDF
