ID   RFC4_CAEEL              Reviewed;         334 AA.
AC   P53016;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Replication factor C subunit 4;
DE   AltName: Full=Activator 1 subunit 4;
GN   Name=rfc-4; ORFNames=F31E3.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC       delta and epsilon requires the action of the accessory proteins PCNA
CC       and activator 1. This subunit may be involved in the elongation of the
CC       multiprimed DNA template (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC       (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P53016; Q18547: rfc-3; NbExp=3; IntAct=EBI-318155, EBI-314981;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; FO080392; CCD63405.1; -; Genomic_DNA.
DR   PIR; T16219; T16219.
DR   RefSeq; NP_498521.1; NM_066120.6.
DR   AlphaFoldDB; P53016; -.
DR   SMR; P53016; -.
DR   BioGRID; 41190; 8.
DR   DIP; DIP-24293N; -.
DR   IntAct; P53016; 7.
DR   MINT; P53016; -.
DR   STRING; 6239.F31E3.3; -.
DR   EPD; P53016; -.
DR   PaxDb; P53016; -.
DR   PeptideAtlas; P53016; -.
DR   EnsemblMetazoa; F31E3.3.1; F31E3.3.1; WBGene00004340.
DR   GeneID; 175976; -.
DR   KEGG; cel:CELE_F31E3.3; -.
DR   UCSC; F31E3.3; c. elegans.
DR   CTD; 175976; -.
DR   WormBase; F31E3.3; CE01268; WBGene00004340; rfc-4.
DR   eggNOG; KOG0989; Eukaryota.
DR   GeneTree; ENSGT00550000074917; -.
DR   HOGENOM; CLU_042324_1_1_1; -.
DR   InParanoid; P53016; -.
DR   OMA; TCEKRIL; -.
DR   OrthoDB; 1071197at2759; -.
DR   PhylomeDB; P53016; -.
DR   Reactome; R-CEL-110312; Translesion synthesis by REV1.
DR   Reactome; R-CEL-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-CEL-110320; Translesion Synthesis by POLH.
DR   Reactome; R-CEL-174411; Polymerase switching on the C-strand of the telomere.
DR   Reactome; R-CEL-176187; Activation of ATR in response to replication stress.
DR   Reactome; R-CEL-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR   Reactome; R-CEL-5655862; Translesion synthesis by POLK.
DR   Reactome; R-CEL-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-CEL-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-CEL-5696400; Dual Incision in GG-NER.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-CEL-69091; Polymerase switching.
DR   PRO; PR:P53016; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004340; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IMP:WormBase.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..334
FT                   /note="Replication factor C subunit 4"
FT                   /id="PRO_0000121758"
FT   BINDING         55..62
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   334 AA;  37706 MW;  FBADEFE1CEF8DAC8 CRC64;
     MEEPMEVDNK RPKVLTWTEK YRPKTLDDIA YQDEVVTMLK GALQGRDLPH LLFYGPPGTG
     KTSAALAFCR QLFPKNIFHD RVLDLNASDE RGIAVVRQKI QSFSKSSLGH SHREDVLKLK
     IIILDEVDAM TREAQAAMRR VIEDFSKTTR FILICNYVSR LIPPVVSRCA KFRFKSLPAE
     IQVQRLRTIC DAEGTPMSDD ELKQVMEYSE GDLRRAVCTL QSLAPILKSG DDNARNCYLR
     GSSDSLLISN VCKSILTADV PQIIALTKDI TKSCTGVAFI RRCFQQLMDE DVINDENIGV
     MGKLVATCEK RILDGCDLEN NLLDFLLTLR ETIQ