ID   RFC4_DICDI              Reviewed;         347 AA.
AC   Q54MD4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable replication factor C subunit 4;
DE   AltName: Full=Activator 1 subunit 4;
GN   Name=rfc4; ORFNames=DDB_G0286027;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC       delta and epsilon requires the action of the accessory proteins PCNA
CC       and activator 1. This subunit may be involved in the elongation of the
CC       multiprimed DNA template (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC       (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000085; EAL64392.1; -; Genomic_DNA.
DR   RefSeq; XP_637900.1; XM_632808.1.
DR   AlphaFoldDB; Q54MD4; -.
DR   SMR; Q54MD4; -.
DR   STRING; 44689.DDB0232233; -.
DR   PaxDb; Q54MD4; -.
DR   EnsemblProtists; EAL64392; EAL64392; DDB_G0286027.
DR   GeneID; 8625410; -.
DR   KEGG; ddi:DDB_G0286027; -.
DR   dictyBase; DDB_G0286027; rfc4.
DR   eggNOG; KOG0989; Eukaryota.
DR   HOGENOM; CLU_042324_1_0_1; -.
DR   InParanoid; Q54MD4; -.
DR   OMA; KIVMVFS; -.
DR   PhylomeDB; Q54MD4; -.
DR   Reactome; R-DDI-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-69091; Polymerase switching.
DR   PRO; PR:Q54MD4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005663; C:DNA replication factor C complex; ISS:dictyBase.
DR   GO; GO:0031391; C:Elg1 RFC-like complex; ISS:dictyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; ISS:dictyBase.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; ISS:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..347
FT                   /note="Probable replication factor C subunit 4"
FT                   /id="PRO_0000330460"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   347 AA;  38855 MW;  4B47C730EF684822 CRC64;
     MSKIQKKDTE PWVAKYRPKT VDDVSYQEDV ISALKKSLNT GNLPHLLFYG PPGTGKTSTI
     LAIAMDIYGP ELMKQRVLEL NASDERGIEV VRTKIKNFAG YAVNKTTTGT SNPGATFKLI
     ILDEADSMTT DAQAALRRTI ETTSKTTRFC LLCNYISRII DPLASRCAKF RFKPLDTVAT
     IERLKFISQQ EGIKCEESVY QAIQVVSNGD MRKAITYLQS AFRFFANKIS EDVIYNIAGS
     LPPQLIKQLV DCCKKNSFDR LQSMVQSIIA QGYPVSQVIS QLFDYVLTTK DLNQSQKSHI
     TMKIGNVDRN LIDGSEEFLQ LFDLSSYIMK QLNNNSTSTN GDDMLIG