ID   RFC4_ORYSJ              Reviewed;         335 AA.
AC   Q7XRX1; Q948P2;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Replication factor C subunit 4;
DE            Short=OsRFC4;
DE   AltName: Full=Activator 1 subunit 4;
GN   Name=RFC4; OrderedLocusNames=Os04g0569000, LOC_Os04g48060;
GN   ORFNames=OSJNBb0032E06.6;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, AND GENE FAMILY.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=14756303; DOI=10.1023/b:plan.0000009258.04711.62;
RA   Furukawa T., Ishibashi T., Kimura S., Tanaka H., Hashimoto J.,
RA   Sakaguchi K.;
RT   "Characterization of all the subunits of replication factor C from a higher
RT   plant, rice (Oryza sativa L.), and their relation to development.";
RL   Plant Mol. Biol. 53:15-25(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: May be involved in DNA replication and thus regulate cell
CC       proliferation. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC       form a complex with RFC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, shoot apical meristem
CC       (SAM), flag leaves and panicles. {ECO:0000269|PubMed:14756303}.
CC   -!- INDUCTION: Down-regulated by sucrose starvation.
CC       {ECO:0000269|PubMed:14756303}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AB066661; BAB69675.1; -; mRNA.
DR   EMBL; AL663003; CAE02250.2; -; Genomic_DNA.
DR   EMBL; AP008210; BAF15508.1; -; Genomic_DNA.
DR   EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q7XRX1; -.
DR   SMR; Q7XRX1; -.
DR   STRING; 4530.OS04T0569000-01; -.
DR   PaxDb; Q7XRX1; -.
DR   PRIDE; Q7XRX1; -.
DR   eggNOG; KOG0991; Eukaryota.
DR   HOGENOM; CLU_042324_0_1_1; -.
DR   InParanoid; Q7XRX1; -.
DR   PlantReactome; R-OSA-9675815; Leading strand synthesis.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   Genevisible; Q7XRX1; OS.
DR   GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..335
FT                   /note="Replication factor C subunit 4"
FT                   /id="PRO_0000422637"
FT   BINDING         56..63
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2
FT                   /note="D -> A (in Ref. 1; BAB69675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        10
FT                   /note="D -> A (in Ref. 1; BAB69675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        32
FT                   /note="G -> V (in Ref. 1; BAB69675)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        43
FT                   /note="D -> V (in Ref. 1; BAB69675)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   335 AA;  36916 MW;  F044E642C605236D CRC64;
     MDASSSSAPD LADAYDIPWV EKYRPTRVAD VGGNSDAVAR LQDIARDGNM PNLILSGPPG
     TGKTTSILSL AHELLGPSYR EAVLELNASD DRGLDVVRNK IKMFAQKKVT LQPGRHKIVI
     LDEADSMTSG AQQALRRTME IYSNTTRFAL ACNTSSKIIE PIQSRCAIVR FSRLSDQEIL
     GRLMIVVAAE KVPYVPEGLE AIIFTADGDM RQALNNLQAT VSGFRFVNQE NVFKVCDQPH
     PLHVKNMVKN VLDGKFDEAC SALKQLYDLG YSPTDIITTL FRVIKNYDMA EYLKLELLKE
     TGFAHMRICD GVGSFLQLSG LLAKFALVRE TAKAS