RFC5_CAEEL
ID RFC5_CAEEL Reviewed; 368 AA.
AC P34429; Q8ST15;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Probable replication factor C subunit 5;
DE AltName: Full=Activator 1 subunit 5;
GN ORFNames=F44B9.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC delta and epsilon requires the action of the accessory proteins
CC proliferating cell nuclear antigen (PCNA) and activator 1.
CC {ECO:0000250}.
CC -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC {ECO:0000305}.
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DR EMBL; FO080400; CCD63451.1; -; Genomic_DNA.
DR PIR; S44809; S44809.
DR RefSeq; NP_498750.2; NM_066349.4.
DR AlphaFoldDB; P34429; -.
DR SMR; P34429; -.
DR BioGRID; 41337; 5.
DR DIP; DIP-27001N; -.
DR IntAct; P34429; 2.
DR STRING; 6239.F44B9.8; -.
DR EPD; P34429; -.
DR PaxDb; P34429; -.
DR PeptideAtlas; P34429; -.
DR EnsemblMetazoa; F44B9.8.1; F44B9.8.1; WBGene00018409.
DR GeneID; 176131; -.
DR KEGG; cel:CELE_F44B9.8; -.
DR UCSC; F44B9.8; c. elegans.
DR CTD; 176131; -.
DR WormBase; F44B9.8; CE37518; WBGene00018409; -.
DR eggNOG; KOG0990; Eukaryota.
DR GeneTree; ENSGT00550000075072; -.
DR HOGENOM; CLU_042324_2_0_1; -.
DR InParanoid; P34429; -.
DR OMA; LVIMDEC; -.
DR OrthoDB; 1071197at2759; -.
DR PhylomeDB; P34429; -.
DR Reactome; R-CEL-110312; Translesion synthesis by REV1.
DR Reactome; R-CEL-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR Reactome; R-CEL-110320; Translesion Synthesis by POLH.
DR Reactome; R-CEL-174411; Polymerase switching on the C-strand of the telomere.
DR Reactome; R-CEL-176187; Activation of ATR in response to replication stress.
DR Reactome; R-CEL-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR Reactome; R-CEL-5655862; Translesion synthesis by POLK.
DR Reactome; R-CEL-5656169; Termination of translesion DNA synthesis.
DR Reactome; R-CEL-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR Reactome; R-CEL-5696400; Dual Incision in GG-NER.
DR Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-CEL-69091; Polymerase switching.
DR PRO; PR:P34429; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00018409; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013748; Rep_factorC_C.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF08542; Rep_fac_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..368
FT /note="Probable replication factor C subunit 5"
FT /id="PRO_0000121753"
FT BINDING 69..76
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 368 AA; 41175 MW; 807B1A4767F1F871 CRC64;
MGSRTGSREE HSLQFLNLTK MTTTTASNLP WVEKYRPSKL DELVAHEQIV KTLTKFIENR
TLPHLLFYGP PGTGKTTTVL AAARQMYSPT KMASMVLELN ASDERGIDVV RNTIVNFAQT
KGLQAFSTSS NTGTVPFKLV ILDEADAMTK DAQNALRRVI EKYTDNVRFC IICNYLASIV
PAIQSRCTRF RFAPLDQKLI VPRLEYIVET EQLKMTPDGK DALLIVSKGD MRTVINTLQS
TAMSFDTVSE NTVYQCIGQP TPKEMKEVVK TLLNDPSKKC MNTIQTKLFE NGYALQDVIT
HLHDFVFTLD IPDEAMSAII TGLGEVEENL STGCSNETQL AAVVAAFFEA KRLCVKEMKN
LEIEDMEF
