ID   RFC5_DICDI              Reviewed;         347 AA.
AC   Q54ST4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable replication factor C subunit 5;
DE   AltName: Full=Activator 1 subunit 5;
GN   Name=rfc5; ORFNames=DDB_G0282235;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC       delta and epsilon requires the action of the accessory proteins PCNA
CC       and activator 1. {ECO:0000250}.
CC   -!- SUBUNIT: Heteropentamer of various rfc subunits that forms a complex
CC       (RFC) with PCNA in the presence of ATP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000046; EAL66323.1; -; Genomic_DNA.
DR   RefSeq; XP_640301.1; XM_635209.1.
DR   AlphaFoldDB; Q54ST4; -.
DR   SMR; Q54ST4; -.
DR   STRING; 44689.DDB0232229; -.
DR   PaxDb; Q54ST4; -.
DR   EnsemblProtists; EAL66323; EAL66323; DDB_G0282235.
DR   GeneID; 8623477; -.
DR   KEGG; ddi:DDB_G0282235; -.
DR   dictyBase; DDB_G0282235; rfc5.
DR   eggNOG; KOG0990; Eukaryota.
DR   HOGENOM; CLU_042324_2_0_1; -.
DR   InParanoid; Q54ST4; -.
DR   OMA; TRTIFCG; -.
DR   PhylomeDB; Q54ST4; -.
DR   Reactome; R-DDI-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-69091; Polymerase switching.
DR   PRO; PR:Q54ST4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005663; C:DNA replication factor C complex; ISS:dictyBase.
DR   GO; GO:0031391; C:Elg1 RFC-like complex; ISS:dictyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; ISS:dictyBase.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; ISS:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..347
FT                   /note="Probable replication factor C subunit 5"
FT                   /id="PRO_0000330459"
FT   BINDING         64..71
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   347 AA;  39589 MW;  9A3C81849F08C760 CRC64;
     MEIDMADKTN KFKTDIERKQ FESLPWVEKY RPKNLDDLIA HEDITQTITK LIDNNTLPHL
     LFYGPPGTGK TSTIQAIARK LYGDNYSRMV LELNASDDRG IDVVREQIKT FASSMFFFNT
     TVPYKLIILD EADSMTNIAQ TALRRVIEKY TKTTRFCIVC NYVIKIIPAL QSRCTRFRFS
     PLPTPPTEIR LKEIIEKENV KVDSKAMNAV LELGCGDMRK CLNILQSVSM SSIDNNITEE
     AIYKCTGYPM PSDIELMVDW LLNSDYEEAF QNISDLKKKK GLSLNDIIAT LQKFVVQIDL
     DNVILCKLLS HLSDIEYNLS IGSSEKLQLG SLVGCFQLSR DDELLHN