ID   RFC5_NEUCR              Reviewed;         352 AA.
AC   Q8X082; Q7SCB8;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Replication factor C subunit 5;
DE            Short=Replication factor C5;
DE   AltName: Full=Probable activator 1 subunit 5;
GN   ORFNames=B14D6.460, NCU06769;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: The elongation of primed DNA templates by DNA polymerase
CC       delta and epsilon requires the action of the accessory proteins
CC       proliferating cell nuclear antigen (PCNA) and activator 1.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heteropentamer of subunits rfc1, rfc2, rfc3, rfc4 and rfc5
CC       that forms a complex with PCNA in the presence of ATP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AL356173; CAB91755.2; -; Genomic_DNA.
DR   EMBL; CM002237; EAA34305.1; -; Genomic_DNA.
DR   RefSeq; XP_963541.1; XM_958448.2.
DR   AlphaFoldDB; Q8X082; -.
DR   SMR; Q8X082; -.
DR   STRING; 5141.EFNCRP00000006881; -.
DR   EnsemblFungi; EAA34305; EAA34305; NCU06769.
DR   GeneID; 3879665; -.
DR   KEGG; ncr:NCU06769; -.
DR   VEuPathDB; FungiDB:NCU06769; -.
DR   HOGENOM; CLU_042324_5_0_1; -.
DR   InParanoid; Q8X082; -.
DR   OMA; LMCEACK; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0031390; C:Ctf18 RFC-like complex; IBA:GO_Central.
DR   GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR   GO; GO:0031391; C:Elg1 RFC-like complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031389; C:Rad17 RFC-like complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IEA:UniProt.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..352
FT                   /note="Replication factor C subunit 5"
FT                   /id="PRO_0000121763"
SQ   SEQUENCE   352 AA;  39921 MW;  FEA78B4068C6644D CRC64;
     MALIVDKHRP RSLDALTYHT ELSERLRSLA QSGDFPHLLV YGPSGAGKKT RIVATLKELY
     GPGVEKIKID ARVFQTSSNR KLEFNIVASV YHLEITPSDV GNYDRVVVQD LLKEVAQTQQ
     VDLSAKQRFK VVVINEADHL TRDAQAALRR TMEKYSPNLR LILLANSTAN IIAPIRSRCL
     LVRVAAPTHK EICDVLASSA KKEGWPIVKG LHQRIAEESG RNLRRALLMY EAVYAQNEKV
     TDSTPIPPPD WEALIGQIAK EIMEEHTPAR ILQVRAKLYD LLTHCIPATI ILKTLTFKLI
     PLIDDALKAD VIYWSAFYEH RIRTGTKVIF HLEAFVAKFM RIFEMYLMSM DL