RFCL_AERPE
ID RFCL_AERPE Reviewed; 479 AA.
AC Q9YBS5;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-FEB-2004, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=APE_1524.1;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; BA000002; BAA80523.2; -; Genomic_DNA.
DR PIR; E72633; E72633.
DR AlphaFoldDB; Q9YBS5; -.
DR SMR; Q9YBS5; -.
DR STRING; 272557.APE_1524.1; -.
DR EnsemblBacteria; BAA80523; BAA80523; APE_1524.1.
DR KEGG; ape:APE_1524.1; -.
DR PATRIC; fig|272557.25.peg.1027; -.
DR eggNOG; arCOG00470; Archaea.
DR OMA; GGWTRYG; -.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..479
FT /note="Replication factor C large subunit"
FT /id="PRO_0000135947"
FT REGION 435..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 56..63
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 479 AA; 54806 MW; 0F09E390DB449456 CRC64;
MPIVARSSRV PWVIKYRPKR VEDVVNQDQA KKILVPWFKA WLEGRKPDKR AALLYGPPGV
GKTSLVEAIA SEFNLEMIEL NASDYRRRSD IERIVGAASR KRSMFKRGVV ILLDEVDGIN
PREDAGGIEA LLSVIKTTEN PIVMTANDPW KDFLRPLREV SLMVEFRPLT LTHIVAVLQR
ICEAERIECE REALRYIAER SEGDLRSAIN DLQAVAEGYG RVTLTLAREI VRGREKSIDI
WRTLNQVFYK PRQAWMARKA VSQSEKDYEE LIAWINDNIP RKYGEPSDLF RAFDALARAT
VFLGRAKFGG NWELLSYVFD LMGPGVAYAR MEGEVLKTRY SYPEKIRMMA QLRGVRETRE
KLAEVLAKRL LMSRRAVKTE VLPILHYIFR SSRDPTKPAM IALEYGLTEK MVELLAGQRK
SEILKAMATV KKARLGEKPL EPQEAKARRR GEKASRDEGR KAGKRERKGV GLDFFLGEQ
