ID   RFCL_ARCFU              Reviewed;         479 AA.
AC   O29072;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Replication factor C large subunit;
DE            Short=RFC large subunit;
DE   AltName: Full=Clamp loader large subunit;
DE   AltName: Full=afRFC large subunit;
DE            Short=afRFCla;
GN   Name=rfcL; OrderedLocusNames=AF_1195;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=12384579; DOI=10.1093/nar/gkf584;
RA   Seybert A., Scott D.J., Scaife S., Singleton M.R., Wigley D.B.;
RT   "Biochemical characterisation of the clamp/clamp loader proteins from the
RT   euryarchaeon Archaeoglobus fulgidus.";
RL   Nucleic Acids Res. 30:4329-4338(2002).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. The complex possesses DNA-dependent ATPase
CC       activity which is further stimulated by PCNA.
CC       {ECO:0000269|PubMed:12384579}.
CC   -!- SUBUNIT: Heteropentamer composed of four small subunits (RfcS) and one
CC       large subunit (RfcL). Both subunits interact with PCNA.
CC       {ECO:0000269|PubMed:12384579}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90051.1; -; Genomic_DNA.
DR   PIR; B69399; B69399.
DR   RefSeq; WP_010878691.1; NC_000917.1.
DR   AlphaFoldDB; O29072; -.
DR   SMR; O29072; -.
DR   STRING; 224325.AF_1195; -.
DR   EnsemblBacteria; AAB90051; AAB90051; AF_1195.
DR   GeneID; 24794801; -.
DR   KEGG; afu:AF_1195; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   PhylomeDB; O29072; -.
DR   BRENDA; 3.6.4.B8; 414.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..479
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135948"
FT   REGION          441..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         43..50
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   479 AA;  55511 MW;  E7DE29F972A99DAD CRC64;
     MLWVEKYRPK TLEEVVADKS IITRVIKWAK SWKRGSKPLL LAGPPGVGKT SLALALANTM
     GWEAVELNAS DQRSWRVIER IVGEGAFNET ISDEGEFLSS RIGKLKLIIL DEVDNIHKKE
     DVGGEAALIR LIKRKPAQPL ILIANDPYKL SPELRNLCEM INFKRLTKQQ VARVLERIAL
     KEGIKVDKSV LLKIAENAGG DLRAAINDFQ ALAEGKEELK PEDVFLTKRT QEKDIFRVMQ
     MIFKTKNPAV YNEAMLLDES PEDVIHWVDE NLPLEYSGVE LVNAYEALSR ADIFLGRVRR
     RQFYRLWKYA SYLMTVGVQQ MKEEPKKGFT RYRRPAVWQM LFQLRQKREM TRKILEKIGK
     YSHLSMRKAR TEMFPVIKLL LKELDVDKAA TIAAFYEFTK EELEFLVGEK GDEIWKYVEK
     HGMHRIEDET FLESFVKAEK EEKEESVEEV AEEKPEEERE EPRARKKAGK NLTLDSFFS