ID   RFCL_HALLT              Reviewed;         500 AA.
AC   B9LPV1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Hlac_1810;
OS   Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS   34).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=416348;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34;
RX   PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA   Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA   Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA   Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA   Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA   Woese C.R., Kyrpides N.C.;
RT   "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT   strain ACAM 34.";
RL   Stand. Genomic Sci. 11:70-70(2016).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP001365; ACM57389.1; -; Genomic_DNA.
DR   RefSeq; WP_015910525.1; NC_012029.1.
DR   AlphaFoldDB; B9LPV1; -.
DR   SMR; B9LPV1; -.
DR   STRING; 416348.Hlac_1810; -.
DR   EnsemblBacteria; ACM57389; ACM57389; Hlac_1810.
DR   GeneID; 7399684; -.
DR   KEGG; hla:Hlac_1810; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000000740; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..500
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_1000185052"
FT   REGION          443..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..500
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   500 AA;  53240 MW;  61DFFBA817A56419 CRC64;
     MADWTEKYRP STLSEVRGND KARDAFADWA RSWDDHHEAV VLHGSPGVGK TSAAHALAND
     MGWETVELNA SDQRTADVIE RFAGRAARNA TLGGSAAGGG AAGGDTASRQ LVILDEADNI
     HGNYDRGGAS AITELVKESG QPIVLIANDY YDMARGLRNA TQEIEFRDVS ARSIVPVLRD
     ICRKEGIEFE SDALERIAER NRGDLRGAIN DLQAATEGRD SIAVEDVVTG DRDKALGLFP
     YLDAVLKEES AEEALQSAYA VDETPDDLTK WIENNVLDVY DPSEVVRAYD FLANADVWLG
     RVRATQNYSY WRYATDNAAA GVAAARDGTK GGWTRYGRPQ FWSPSDATAD EVVGQIAAKS
     GCSVATARRE VLPFLEAVTH HCKPRELTVA MAAAYDLDEA GIAFVTGSGE STNKVASIAE
     DAQALREERM EDHAEGAFAG GRHAADDLGA SDGETTNASG TASSSGDDGD ADGTTDGDGS
     DANDGNDDDD DGQAGLSDFV