ID   RFCL_HALS3              Reviewed;         471 AA.
AC   B0R601;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=OE_3305F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AM774415; CAP14170.1; -; Genomic_DNA.
DR   RefSeq; WP_012289363.1; NC_010364.1.
DR   AlphaFoldDB; B0R601; -.
DR   SMR; B0R601; -.
DR   EnsemblBacteria; CAP14170; CAP14170; OE_3305F.
DR   GeneID; 5953049; -.
DR   KEGG; hsl:OE_3305F; -.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   PhylomeDB; B0R601; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..471
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_1000195420"
FT   REGION          422..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   471 AA;  51446 MW;  DCF3B5329D61CBB1 CRC64;
     MVDWTEKYRP ASLSEVRGND TARDALAEWA ETWPDHREAV VVHGSPGIGK TSAAHALAND
     AGWDVVELNA SDQRTADVVE RVAGEAARSG TLTGGSGGRK LVLLDEADNL HGNIDRGGSA
     AITRLVDDAP QPIVLVANEY YEMSSSLRSA CREIEFRDVS KRSIVPVLRD VCRREDVTYE
     EDALAAIAEQ NAGDLRSAVN DLQALAEQDR TLTADDVVMG ERDRTEGVFD YLDDVIATHS
     AREALQAAYD VDETPDDLLS WVADNVPKDY RGGELADAYE FLSNADVWLG RVRATQNYAY
     WRYATDNVAA GVAAARRHDH GGWTRYGPPS YWRKLGSSRA TREKRDYVAR HIAETAGCSM
     ATARNDVLPF LRVLTHHCKN RELTVAMAAA YELDTEHVAF VTGSGETTNK VASIVADAEE
     RRTDAAVDHS EGAFAGAVRE DNTDEDSAAD ETTDGDEDTG ADSQRGLDEF F