RFCL_HALSA
ID RFCL_HALSA Reviewed; 471 AA.
AC Q9HPI4;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-FEB-2004, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; Synonyms=rfcB;
GN OrderedLocusNames=VNG_1622G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG19883.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE004437; AAG19883.1; ALT_INIT; Genomic_DNA.
DR PIR; G84314; G84314.
DR RefSeq; WP_012289363.1; NC_002607.1.
DR AlphaFoldDB; Q9HPI4; -.
DR SMR; Q9HPI4; -.
DR STRING; 64091.VNG_1622G; -.
DR PaxDb; Q9HPI4; -.
DR EnsemblBacteria; AAG19883; AAG19883; VNG_1622G.
DR GeneID; 5953049; -.
DR KEGG; hal:VNG_1622G; -.
DR PATRIC; fig|64091.14.peg.1236; -.
DR HOGENOM; CLU_027255_1_0_2; -.
DR InParanoid; Q9HPI4; -.
DR OrthoDB; 24257at2157; -.
DR PhylomeDB; Q9HPI4; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..471
FT /note="Replication factor C large subunit"
FT /id="PRO_0000135950"
FT REGION 422..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 471 AA; 51446 MW; DCF3B5329D61CBB1 CRC64;
MVDWTEKYRP ASLSEVRGND TARDALAEWA ETWPDHREAV VVHGSPGIGK TSAAHALAND
AGWDVVELNA SDQRTADVVE RVAGEAARSG TLTGGSGGRK LVLLDEADNL HGNIDRGGSA
AITRLVDDAP QPIVLVANEY YEMSSSLRSA CREIEFRDVS KRSIVPVLRD VCRREDVTYE
EDALAAIAEQ NAGDLRSAVN DLQALAEQDR TLTADDVVMG ERDRTEGVFD YLDDVIATHS
AREALQAAYD VDETPDDLLS WVADNVPKDY RGGELADAYE FLSNADVWLG RVRATQNYAY
WRYATDNVAA GVAAARRHDH GGWTRYGPPS YWRKLGSSRA TREKRDYVAR HIAETAGCSM
ATARNDVLPF LRVLTHHCKN RELTVAMAAA YELDTEHVAF VTGSGETTNK VASIVADAEE
RRTDAAVDHS EGAFAGAVRE DNTDEDSAAD ETTDGDEDTG ADSQRGLDEF F
