ID   RFCL_HALWD              Reviewed;         516 AA.
AC   Q18GQ9;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=HQ_2729A;
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=362976;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001;
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA   Pfeiffer F., Oesterhelt D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AM180088; CAJ52837.1; -; Genomic_DNA.
DR   RefSeq; WP_011571952.1; NC_008212.1.
DR   AlphaFoldDB; Q18GQ9; -.
DR   SMR; Q18GQ9; -.
DR   STRING; 362976.HQ_2729A; -.
DR   EnsemblBacteria; CAJ52837; CAJ52837; HQ_2729A.
DR   GeneID; 4194576; -.
DR   KEGG; hwa:HQ_2729A; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..516
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000292179"
FT   REGION          421..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..496
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..516
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         44..51
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   516 AA;  56342 MW;  46D91A1FBC65CF37 CRC64;
     MTDWTERYRP TTLSAVRGNN AARDEFIEWA ESWDDHHESV VLHGAPGVGK TSAAHALASD
     MGWETVELNA SDQRTSDVIE RLAGRAAKNA TLAGAVSGTT STRQLIIMDE ADNIHYQYDR
     GGKQAVTTLL KDANQPIVLI ANEYYDMSRG LRNAAQDIEF RDISARSIVP VLRNILRKEN
     IEFEEAALKQ IAEVNSGDLR AAIKDLQTTV EGSDRITVDD VKTGGRDRAM GLFSFLDSVL
     KEDAAEEALQ NSYDVDETPD DLLKWVEDKV PLVYDDAELA RAYEFLSNAD IWTNRVYATD
     YNYRWWRYAT DNLAGGVAAA RETQRGGWTR YGGAPYRSTR DSTRDTVVRE VAKTGGFSMA
     TARTAVIPFL SAITHLCKPR SLTVGMAAWY ELDEAGVSYI TGSGETTKKV ASIVEDAAER
     RSEAVEAHAG SAFAETETEE KTNFTGNQDS DVDVQSHKSA ESGDDTVRTA NTPAEDHAQS
     GASETASATE SASDSDASTD TDADDDDGQA GLSEFM