ID   RFCL_IGNH4              Reviewed;         476 AA.
AC   A8AC24;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Igni_1300;
OS   Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Ignicoccus.
OX   NCBI_TaxID=453591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIN4/I / DSM 18386 / JCM 14125;
RX   PubMed=19000309; DOI=10.1186/gb-2008-9-11-r158;
RA   Podar M., Anderson I., Makarova K.S., Elkins J.G., Ivanova N., Wall M.A.,
RA   Lykidis A., Mavromatis K., Sun H., Hudson M.E., Chen W., Deciu C.,
RA   Hutchison D., Eads J.R., Anderson A., Fernandes F., Szeto E., Lapidus A.,
RA   Kyrpides N.C., Saier M.H. Jr., Richardson P.M., Rachel R., Huber H.,
RA   Eisen J.A., Koonin E.V., Keller M., Stetter K.O.;
RT   "A genomic analysis of the archaeal system Ignicoccus hospitalis-
RT   Nanoarchaeum equitans.";
RL   Genome Biol. 9:R158.1-R158.18(2008).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000816; ABU82476.1; -; Genomic_DNA.
DR   RefSeq; WP_012123440.1; NC_009776.1.
DR   AlphaFoldDB; A8AC24; -.
DR   SMR; A8AC24; -.
DR   STRING; 453591.Igni_1300; -.
DR   PRIDE; A8AC24; -.
DR   EnsemblBacteria; ABU82476; ABU82476; Igni_1300.
DR   GeneID; 5562218; -.
DR   KEGG; iho:Igni_1300; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   PhylomeDB; A8AC24; -.
DR   Proteomes; UP000000262; Chromosome.
DR   GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08519; RFC1; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000318539"
FT   REGION          447..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   476 AA;  54711 MW;  96A75D71CA8BBB5E CRC64;
     MSAVPWIIKY RPKRVEDVID QEKAKEVLIP WIKKWLSGTP PEKRAALLWG PPGVGKTSLV
     EAICNEFNLE KIEMNASDFR RKGDIERVAI AAATKKPLPP WKGRLILLDE VDGLSPRGDE
     GAVAAILELI KKTKNPIVMT ANDPWGTHLR PIREESLLVE FKRIPKTKAR EFLLKICEKE
     GVYCEKEAVD YIIEKNKGDL RASINDLQSI AEAYGKVTLD LASALLVERD RVLTPWEMLQ
     SLFYSKYSWQ ARKAVTSTDL DYDTLFLWIA ENVPKQYGDD PYDLWRGMEA VSRADVIYGR
     IRRTMNWSLL PYFFNALGPG VALAKTKYHK RARWSYPEKI VLLARTKEER RVRDELASHL
     ALLTHSSKSY VRREIIPMLQ FIAQVNPNYF ARLALGLRLS DPMIKYLAKS KYQLVKKYVE
     ELKSSRTVKA EEQTKAKEVV KELKKEYEKG TKKGKGEKRR KGSDEGSGLL KWLKKD