RFCL_META3
ID RFCL_META3 Reviewed; 474 AA.
AC A6UWR5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Maeo_1361;
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; CP000743; ABR56937.1; -; Genomic_DNA.
DR RefSeq; WP_011974069.1; NC_009635.1.
DR AlphaFoldDB; A6UWR5; -.
DR SMR; A6UWR5; -.
DR STRING; 419665.Maeo_1361; -.
DR EnsemblBacteria; ABR56937; ABR56937; Maeo_1361.
DR GeneID; 5326564; -.
DR KEGG; mae:Maeo_1361; -.
DR eggNOG; arCOG00470; Archaea.
DR HOGENOM; CLU_027255_1_0_2; -.
DR OMA; GGWTRYG; -.
DR OrthoDB; 24257at2157; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..474
FT /note="Replication factor C large subunit"
FT /id="PRO_1000024484"
FT REGION 415..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 45..52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 474 AA; 54073 MW; 20868BDED453D285 CRC64;
MNWVEKYRPK TMSEIVGNNK IKEELKNWIE EILHNEIPKP VLLVGPPGCG KTTLTNALAN
DYGFELIELN ASDKRNKDII RQIVGGASSS KSITGKRVLI VLDEVDGLSG NSDRGGVSEI
IKIIKNAKNP IILTANDIYK PSLMSLRTVC NIVKIGSVHT NSIVPVLRRI SLKEGFEVDD
KILKIIAKHA GGDVRSAIND LESLAMGNTF DEDNVRELPD RDTDKSIFDA IRIIFKTTHY
DISLEATRDL KEDIGTVQEW IAENVPREYK KGKEICLAYD NLSKADIFLG RVYKRQYYGL
WRYASALMSA GVSLAKDEKY RGFFSYMRPT IFTKMSRSKG KRGAVNKVLE KISLKSHVSK
RRAREDILYL EYILKNDAEM GAKLCEFYEF TKEDIEYLTN KTIAKKIIKL MKGDDKKTNN
KKGKENKTKN TTKKIKEIKE TPKKEEVKEP KKQIEKQKSE KKEPKKQMTL ESFF
