ID   RFCL_METAR              Reviewed;         553 AA.
AC   Q0W3P4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=UNCMA_12400;
GN   ORFNames=RCIX1805;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AM114193; CAJ36999.1; -; Genomic_DNA.
DR   RefSeq; WP_012035568.1; NC_009464.1.
DR   AlphaFoldDB; Q0W3P4; -.
DR   SMR; Q0W3P4; -.
DR   STRING; 351160.RCIX1805; -.
DR   EnsemblBacteria; CAJ36999; CAJ36999; RCIX1805.
DR   GeneID; 5143194; -.
DR   KEGG; rci:RCIX1805; -.
DR   PATRIC; fig|351160.9.peg.1276; -.
DR   eggNOG; arCOG00470; Archaea.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..553
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000292187"
FT   REGION          438..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..493
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   553 AA;  61066 MW;  E807CF7AAAE43C03 CRC64;
     MTADNDTRDW TEKYRPVSLA DIVGNDAAVK ALRQWAETFG TGKKAVILYG GPGVGKTSAA
     LALAHDMGWD YIELNASDVR TKDAINRIAG PAAMAGTFEG TGGRRLVILD EADNLHGNYD
     RGGEAAIINV IRNASQPVIL IANDMYAMSK PLRESALQIQ FRAILSTSVA KVLRKVCANE
     GLKCDPEALM KIAERTNDLR SAINDLQAAA QGSGQVTVAD VSTGDRDVPE TIFKVMGMIF
     RGKNMREALN ATYGLDENPE DLIGWVDENL PREYQDDDLE RGFEALSRAD VYLGRTRRRQ
     DYGMWRYAGF MMVCGVNRAR RRHYGGFSRY SPPTYWQKLG RAKSTRVTRD SIAAKVGKAC
     HCSKAEARST YLPLLRFLFD KDEYAIRLSA QLKLEEDEIA FLLDAKKASK KVGEIYKKSR
     ALIEEEIEEE IDLFARFGKR PGKPEAGEPR ESLFMAGEEE EKPSREKSAK LDAFGEIEKP
     KRKRRKAPDG GAPIEDGPEE PGEAPMAAAM PAATESFGPA GAPAPQESPL PEPEKPPAAE
     DKCSKKQRTL FDF