RFCL_METB6
ID RFCL_METB6 Reviewed; 481 AA.
AC A7I781;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Mboo_1074;
OS Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=456442;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21154 / JCM 14090 / 6A8;
RX PubMed=25998264; DOI=10.1099/mic.0.000117;
RA Braeuer S., Cadillo-Quiroz H., Kyrpides N., Woyke T., Goodwin L.,
RA Detter C., Podell S., Yavitt J.B., Zinder S.H.;
RT "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic
RT peatland environments.";
RL Microbiology 161:1572-1581(2015).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; CP000780; ABS55592.1; -; Genomic_DNA.
DR RefSeq; WP_012106619.1; NC_009712.1.
DR AlphaFoldDB; A7I781; -.
DR SMR; A7I781; -.
DR STRING; 456442.Mboo_1074; -.
DR EnsemblBacteria; ABS55592; ABS55592; Mboo_1074.
DR GeneID; 5409802; -.
DR KEGG; mbn:Mboo_1074; -.
DR eggNOG; arCOG00470; Archaea.
DR HOGENOM; CLU_027255_1_0_2; -.
DR OMA; GGWTRYG; -.
DR OrthoDB; 24257at2157; -.
DR Proteomes; UP000002408; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..481
FT /note="Replication factor C large subunit"
FT /id="PRO_1000024485"
FT REGION 408..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 481 AA; 53037 MW; DE35825753AA7BD9 CRC64;
MEWAEKYRPE HLADIVGNTS AVRQMADWAK TWTARSKPLL LYGKPGIGKT SSVYALARDM
NWDVIELNAS DQRTAAVIER IAGAGSTTAS LTGSARKLII MDEADNLQGT ADRGGAKAIL
ECIKNARQPI VLIANDLYGL AAELRLRCEP VQFRALPARS IAPRLKYICS SEKIACSESA
VHEIAESAEG DMRSAVNMLY ASAIGRQSLD GKNVHTSQKD ERVSIFSLVT AVFGKTSDEE
LIRLSRDVDE FPEDIEQWVE GSVHTITDPA GLGLAYRSLS RADEYIGYTY RRQYHTLWRY
ATAVMLLGVA DASAGKGIHS RILPPERWQK MSVAKKQKAI RAAVLSRLAA TMQLPQATLR
EKYMDIITLL VDLDPETFAR ELALDADGLN FFLNDKSRAQ EILKSLAKVE REKEPEPKKK
GRKKAESPAK DADPAPAVDP VPKEELPVKS APEERPADPP APEEPGRKTV AHNQSTLFDG
F
