ID   RFCL_METBU              Reviewed;         497 AA.
AC   Q12TX1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Mbur_2242;
OS   Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS   ACE-M).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M;
RX   PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA   Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA   De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA   Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA   Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA   Cavicchioli R.;
RT   "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT   burtonii: the role of genome evolution in cold adaptation.";
RL   ISME J. 3:1012-1035(2009).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000300; ABE53105.1; -; Genomic_DNA.
DR   RefSeq; WP_011500241.1; NC_007955.1.
DR   AlphaFoldDB; Q12TX1; -.
DR   SMR; Q12TX1; -.
DR   STRING; 259564.Mbur_2242; -.
DR   EnsemblBacteria; ABE53105; ABE53105; Mbur_2242.
DR   GeneID; 3998854; -.
DR   KEGG; mbu:Mbur_2242; -.
DR   HOGENOM; CLU_027255_0_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   Proteomes; UP000001979; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..497
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000292181"
FT   REGION          428..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..480
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   497 AA;  55694 MW;  3E4933C17028D0CC CRC64;
     MAESIEWVEK YRPQSLTDIV GNKKSVVDMR EWAQSWLSGT PEKRAIILHG PAGVGKTSAA
     HALARDLDWE TIELNASDQR TAGVIERVAG SASKMSSLTG TTAKRLIILD EADNIHGNAD
     RGGARAIGGI IKNTDQPIVL IANDLYGLTP SVRSLCIELK FNSVQGRSMI PAMKRICVEE
     KIMCGVGVLE KLAESAGGDL RSAIKDLQAV ATGRDEIHIE DIATSERDTK ESIFKVLGKI
     FKSTDPKKAL EATYGLDETP ENLIHWIDEN LPLQYGTEEG TQEDLITGYE YLAKADRYLG
     RVRKRQSYRL WRYAGALMTC GTVVSKTHVG RGFTKYQPPS FWRKMGQLRA KRDMRDNIAS
     KIADHANKSM RYSRTDLAHL YGRMLEENEY AADVTFDLEL SIDEMVYLTG KKKVTKDIQR
     IHDLAQAKRR SLGRDEGKAF FEKKPKKQTP DKKQMDLTQI INSTPQEDKV EKKETENVPP
     VKKSASKAKP QKTLFDF