ID   RFCL_METKA              Reviewed;         510 AA.
AC   Q8TZC5;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=MK0005;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AE009439; AAM01222.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TZC5; -.
DR   SMR; Q8TZC5; -.
DR   STRING; 190192.MK0005; -.
DR   PRIDE; Q8TZC5; -.
DR   EnsemblBacteria; AAM01222; AAM01222; MK0005.
DR   KEGG; mka:MK0005; -.
DR   PATRIC; fig|190192.8.peg.5; -.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..510
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135953"
FT   REGION          459..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..488
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         48..55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   510 AA;  58255 MW;  E3676E6348A8DED2 CRC64;
     MVPWVEKYRP RSLKELVNQD EAKKELAAWA NEWARGSIPE PRAVLLHGPP GTGKTSAAYA
     LAHDFGWDVI ELNASDKRTR NVIEKIVGGA STSRSLLRMT REAGGDYEHV EGHSDRVLVL
     VDEVDGIDPR EDRGGVTALT RAVRQARNPM VLVANDPWVL PKSLRDAVRM IEFRRLRVND
     IVEALRRICE REGIEYEEVA LRRIAKRARG DLRAAINDLE ALARPTGRVT SDDVEALGWR
     DKEITIFEAL GRIFNKPPRQ ARRALWNLDE DPDDVILWIA QNIPRAYRDP EEIARAYDYL
     SKADVFSSRA IETGDWRFKY VYATDLMTSG VAAARKGKPP GFVRFQPPKI LRKLGTTRKE
     REVRNSIAKK IAERMHVSTR RAKMDVISVL EIAFRKVADN PTDRGLEILG GIAGYLELSK
     REIGFLCGDP QVAQRVYQRA LRVREKLRKI RRERVKGAME SMLERKREES EVEEEAKEIE
     EAVEKAEEEE EREEKKKEGG GEQRTLDAFF