RFCL_METLZ
ID RFCL_METLZ Reviewed; 476 AA.
AC A2SQR6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Mlab_0498;
OS Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX NCBI_TaxID=410358;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43576 / DSM 4855 / Z;
RX PubMed=21304657; DOI=10.4056/sigs.35575;
RA Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL Stand. Genomic Sci. 1:197-203(2009).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; CP000559; ABN06672.1; -; Genomic_DNA.
DR RefSeq; WP_011832873.1; NC_008942.1.
DR AlphaFoldDB; A2SQR6; -.
DR SMR; A2SQR6; -.
DR STRING; 410358.Mlab_0498; -.
DR EnsemblBacteria; ABN06672; ABN06672; Mlab_0498.
DR GeneID; 4795947; -.
DR KEGG; mla:Mlab_0498; -.
DR eggNOG; arCOG00470; Archaea.
DR HOGENOM; CLU_027255_1_0_2; -.
DR OMA; GGWTRYG; -.
DR OrthoDB; 24257at2157; -.
DR Proteomes; UP000000365; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT CHAIN 1..476
FT /note="Replication factor C large subunit"
FT /id="PRO_0000292182"
FT REGION 435..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 476 AA; 52843 MW; 69DF244F24FE568C CRC64;
MDWAEKYRPM HLADILGNGS AVRQIVDWAK TWTPDSRPLL FTGKPGIGKT SAALALARDM
DWEVLELNAS DARTKTIIER VAGNSSTTTS LFGAGRKLII IDEVDNLEGN ADRGGARAIA
DILKEAKQPI VLIANDAYGV SDSIRRLCDP VPFRAIGVST LQKRMKEICR FEDIACGEDA
LSAIAESSAG DMRTAVNMLF GSSTGKTSIS VGDINTAQKD ERATIFDLVG GVFAGAPDRE
LQKLSFECDE KPDSVMQWIE ESIPLMHDPK RRIRAYGRIS RADVYLGRTM RRQYFTLWRY
ATSMMTLGVA SENAGAGFRT RIMPPSRWKR MSTAKKQKTV RRTLAASLAE GYSIPERQIQ
SEYLDLLSRF AEKDPAAFCE RHNLDVDQMG IILHDKAAAA AAVKTVQQAA KERDMKVKKM
AASKKAEMRK LEEQLEALRM QEPPVPETPP AAEEQPLEEP QEEKKLAPKQ ATLDFF
