ID   RFCL_METM5              Reviewed;         484 AA.
AC   A4FZL6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=MmarC5_1352;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000609; ABO35650.1; -; Genomic_DNA.
DR   RefSeq; WP_011869101.1; NC_009135.1.
DR   AlphaFoldDB; A4FZL6; -.
DR   SMR; A4FZL6; -.
DR   STRING; 402880.MmarC5_1352; -.
DR   EnsemblBacteria; ABO35650; ABO35650; MmarC5_1352.
DR   GeneID; 4928141; -.
DR   KEGG; mmq:MmarC5_1352; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..484
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000318540"
FT   REGION          419..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..438
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   484 AA;  54138 MW;  895757B42FD0DAC9 CRC64;
     MEEWVEKYRP KSLNDVAGHN KTKQALINWI ESFVNGQKQK PILLAGPPGS GKTTLAHAIA
     KDYAFDVIEL NASDKRNKDV IAQVVGTAAT SKSLTGKRTL IVLDEVDGLS GNDDRGGVAE
     IIKVLKTAEN PVILTANDVY KPALMTLRNN VNLINVGSVH TNSIPPVLRK IALKEGFEID
     EKVIKTIASH SGGDLRAAIN DLQSLATGGS LEVEDAKELP DRDSEKSIFD AMRIIMKTTH
     YDIATSATRD VKEDLGTIQE WISENLPKEY LRYKDLAGGY DYLSKSDVFL GRVFKRQYFG
     LWRYASALMT AGTALAKEEK YRGFTRYGPP TIFTKLSRTK GSRQKMKDIL KKIALKTHTS
     TKRARNTLDY LVVIFESNPE VSAELVEYYE LTKLEMEFLT NKTIAKNIFS VIAGKKPKVK
     TETPKKKEKT KEAMPIIPKR PRISEPPEPL KEVITTIEKS VEKADTKEKE KKDPKKQATL
     DSFF