ID   RFCL_METM6              Reviewed;         484 AA.
AC   A9A6N2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=MmarC6_0629;
OS   Methanococcus maripaludis (strain C6 / ATCC BAA-1332).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=444158;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6 / ATCC BAA-1332;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B.,
RA   Richardson P.;
RT   "Complete sequence of Methanococcus maripaludis C6.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000867; ABX01446.1; -; Genomic_DNA.
DR   RefSeq; WP_012193346.1; NC_009975.1.
DR   AlphaFoldDB; A9A6N2; -.
DR   SMR; A9A6N2; -.
DR   STRING; 444158.MmarC6_0629; -.
DR   EnsemblBacteria; ABX01446; ABX01446; MmarC6_0629.
DR   GeneID; 5738894; -.
DR   KEGG; mmx:MmarC6_0629; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   PhylomeDB; A9A6N2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..484
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_1000195421"
FT   REGION          463..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   484 AA;  54448 MW;  24D94F56A047741F CRC64;
     MEEWVEKYRP KSLNDVAGHN KTKETLIEWI ESFVSGQKQK PILLAGPPGS GKTTLAYAIA
     KDYAYDVIEL NASDKRNKDV ISQVVGTAAT SKSITGRRTL IVLDEVDGLS GNDDRGGVAE
     IIKVLKTAEN PVILTANDVY KPALMTLRNN VNLINVGSVH TNSIPPVLRK IALKEGFEID
     EKVIKTIASH AGGDLRAAIN DLQSLATGGS LEVEDAKELP DRDSEKSIFD AMRIIMKTTH
     YDIATSATRD VKEELGTIEE WISENLPKEY LKYKDLANGY DYLSKSDVFL GRVFRRQYFG
     LWRYASALMT AGTALAKEEK YRGFTRYAPP SIFTKLSRTK GTRQKMKDIL KKIALKTHTS
     TKRARNTLDY MVVIFESNPE VSAELVEYYE LTKEEMEFLT NKTITKNIFS VIAGKKPKVE
     KEIPKKKKTE EVMPIIPKRP KISELPKEPL KEVIETIEKS VENADTKEKE KKDPKKQATL
     DSFF