ID   RFCL_METMA              Reviewed;         610 AA.
AC   Q8Q084;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=MM_0253;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AE008384; AAM29949.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8Q084; -.
DR   SMR; Q8Q084; -.
DR   STRING; 192952.MM_0253; -.
DR   EnsemblBacteria; AAM29949; AAM29949; MM_0253.
DR   KEGG; mma:MM_0253; -.
DR   PATRIC; fig|192952.21.peg.307; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_0_0_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..610
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135954"
FT   REGION          467..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..514
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..610
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         55..62
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   610 AA;  67574 MW;  644639BEA1E0BB53 CRC64;
     MVWFKMMSAI EWAEKYRPRT LGDVVGNRKA VQDLRKWAEE WQSGIPEKRA VILYGPAGIG
     KTSSAHALAG DMEWEVIELN ASDQRTAGVI EKIAGSAASM NTFFGGKRLI ILDEADNLHG
     TADRGGMRAI SGIIKSTLQP IILIANDIYG LTPTVRNICL EIKFGSVQSR SMVPALKKVC
     ESEGVSCSQE AVLQIAENAG GDFRSAINDL QAAANGKKAL EAEDISTAGR DVKENIFKAM
     QKIFKSTDCK RALESAYGLD ESPEDLVHWI DENLPIQYAR KDGDLEDIKT GFGYLSKADI
     YLGRVKKRQN YRMWRYASML MVCGAALSKT RPYPGFIKYQ QPSLWRRLGQ TRSRRDMRDN
     IASKIGEHSF ESMHYSRNNL LGFYSILLKD EASAVELTAN LGLELEELMY LSGSAKVSKK
     LQKIYDEAQN LLETKRDRTE EQEFFKAPAP AADDKQATLH CPVNIPEKEG NASAEKPESP
     GPQSPERKQK TLDLGFDTPQ KLPEKKRSSE MKLPENPEPA ENNLFSLSEP LPEKGPIPDF
     AGKKSLPELE EEKPSLSPLK KMSPANKEAS KQGVKQGASE KGSPAADTQG GMEDGSKKAE
     PKNQKTLFDF