RFCL_METMJ
ID RFCL_METMJ Reviewed; 454 AA.
AC A3CTR4;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Memar_0831;
OS Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=368407;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35101 / DSM 1498 / JR1;
RX PubMed=21304656; DOI=10.4056/sigs.32535;
RA Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT type strain JR1.";
RL Stand. Genomic Sci. 1:189-196(2009).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; CP000562; ABN56764.1; -; Genomic_DNA.
DR RefSeq; WP_011843675.1; NC_009051.1.
DR AlphaFoldDB; A3CTR4; -.
DR SMR; A3CTR4; -.
DR STRING; 368407.Memar_0831; -.
DR EnsemblBacteria; ABN56764; ABN56764; Memar_0831.
DR GeneID; 4846444; -.
DR KEGG; mem:Memar_0831; -.
DR eggNOG; arCOG00470; Archaea.
DR HOGENOM; CLU_027255_1_0_2; -.
DR OMA; GGWTRYG; -.
DR OrthoDB; 24257at2157; -.
DR Proteomes; UP000002146; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding.
FT CHAIN 1..454
FT /note="Replication factor C large subunit"
FT /id="PRO_0000292183"
FT REGION 408..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 454 AA; 49886 MW; 39C6A1EAE2F8256E CRC64;
MDWVEKYRPQ HLQDVVGNSG AVRLIYEWAR DWSRQKKPLI LYGKPGTGKT SSAYALANDM
NWEVVELNAS DQRTKAALER VAGAGSTTAS LSGASRKLIL LDEADNLHGQ ADRGGAKAIV
EIIAAAQQPI ILIANDYYSL TRELKAVTEP VQFRALQARS IVPRLRQICA AEGVACDPAA
LDDIANRAGG DMRAAVNMLY AAAIGKEHLA AGDVHTSAKD ERSTIFELVG ATFKGKRDAD
LLRMAVEVED TPDAIEQWLE GNLDHMPDLA SRAEGYACLA RADEYIGRTY RRQYYTLWRY
ASAVMLLGVA DAAGGHGVHG RIMPPSRWQK MGASKKQKAV RAGLSRKLSE MTHIPQDALR
EDFFTAITIL VERDPATYVR EFDLDADELN LFIHDKARAT KVVKEVAKEE KEKAKKAAAK
EKAPTKGKKS RDDDPPADTG ESRRDPSPGQ ATLF
