ID   RFCL_METMP              Reviewed;         486 AA.
AC   Q6M0E9;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; Synonyms=rfcB;
GN   OrderedLocusNames=MMP0322;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; BX950229; CAF29878.1; -; Genomic_DNA.
DR   RefSeq; WP_011170266.1; NC_005791.1.
DR   AlphaFoldDB; Q6M0E9; -.
DR   SMR; Q6M0E9; -.
DR   STRING; 267377.MMP0322; -.
DR   EnsemblBacteria; CAF29878; CAF29878; MMP0322.
DR   GeneID; 2761723; -.
DR   KEGG; mmp:MMP0322; -.
DR   PATRIC; fig|267377.15.peg.325; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   BioCyc; MMAR267377:MMP_RS01720-MON; -.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08519; RFC1; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..486
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135955"
FT   REGION          419..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..480
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   486 AA;  54502 MW;  0FAC6169AABE2DCF CRC64;
     MEEWVEKYRP KSLNDVAGHN KTKQALIEWI ESIIGGQNQK PILLAGPPGS GKTTLAYAIA
     NDYAFDVIEL NASDKRNKDV ISQVVGTAAT SKSLTGRRTL IVLDEVDGLS GNDDRGGVAE
     IIKVLKTAEN PVILTANDVY KPALMTLRNS VNLINVGSVH TNSIPPVLRR IALKEGFEID
     EKIIKMIASH SGGDLRAAIN DLQSLATGGS IEIEDAKELP DRDSEKSIFD AMRIIMKTTH
     YDIATSATRD VKEDIGTIEE WISENLPKEY LKYKDLAEGY DYLSKSDVFL GRVYRRQYFG
     LWRYASALMT AGTALAKEEK YRGFTRYGPP AIFTKLSRTK GSRQKMKDIL KKIALKTHTS
     TKRARNTVDY LTVIFESNAE VSAELVEYYE LTKDEIEFLT NKTITKKILS VIAGKKPKVK
     KETPKKTEKP KEVMPIIPKR PRISEPPKEP LKEVIEETLE KSVEKADTKE EKKKDPKKQA
     TLDSFF