ID   RFCL_METS3              Reviewed;         492 AA.
AC   A5UMF4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Msm_1177;
OS   Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=420247;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35061 / DSM 861 / OCM 144 / PS;
RX   PubMed=17563350; DOI=10.1073/pnas.0704189104;
RA   Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B.,
RA   Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.;
RT   "Genomic and metabolic adaptations of Methanobrevibacter smithii to the
RT   human gut.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000678; ABQ87382.1; -; Genomic_DNA.
DR   RefSeq; WP_011954335.1; NC_009515.1.
DR   AlphaFoldDB; A5UMF4; -.
DR   SMR; A5UMF4; -.
DR   STRING; 420247.Msm_1177; -.
DR   EnsemblBacteria; ABQ87382; ABQ87382; Msm_1177.
DR   GeneID; 5216360; -.
DR   KEGG; msi:Msm_1177; -.
DR   PATRIC; fig|420247.28.peg.1176; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000001992; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..492
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000300154"
FT   REGION          429..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..485
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         45..52
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   492 AA;  56263 MW;  F43B51C4A7689A77 CRC64;
     MLWTDKYRPK TLDEVVGNNK EKALIQKWVD NWKAGNPQKP LLLVGPPGIG KTTLAQAIAR
     EFSEYIELNA SDKRSQDVIK STIGESSSSK SLFGDDYKLL ILDEVDGIHG TNDRGGVRAI
     GDIIKKAKHP MILIANDFYS KRIASLKTKC DVLKMSKVRS PSINKLLKQI AINEGIKANP
     AALKELAKKS NGDMRSAINT FQALANQNEV LELSDIENIT TKDDRSTIIN GVTAVLKSKN
     PNHVKKALMV EEDPTLVMEY IAENIPREYT KKKEIKKAYE NIAKADLYFG RARSSRYYGY
     WKYATDFMGV GVSDAKDETY KKFTRITSPT VFTLMGRNRG KRNLRDRIAE KMSQKLHISH
     SVAISMFPYL EIMFENNELA WEISDFLGFE EDEIKRFRTR KIPKKVIEKM EKQKAQKRVE
     QRDARAQEIQ DGLMATIPPQ KEVKEEPTEE IQEEVVDEIK EETVEEIQEE SQKEVEEKPK
     KKTDKQVSLF NF