ID   RFCL_METTP              Reviewed;         467 AA.
AC   A0B6D7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Mthe_0470;
OS   Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS   PT) (Methanosaeta thermophila).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=349307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT   "Complete sequence of Methanosaeta thermophila PT.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000477; ABK14261.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0B6D7; -.
DR   SMR; A0B6D7; -.
DR   STRING; 349307.Mthe_0470; -.
DR   EnsemblBacteria; ABK14261; ABK14261; Mthe_0470.
DR   KEGG; mtp:Mthe_0470; -.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000000674; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..467
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000292184"
FT   BINDING         47..54
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   467 AA;  52147 MW;  B4083C188D6C5F52 CRC64;
     MTSWAEKYRP KNLDGILGNA KAVSELRAWA MAWEKGRPEV KCLILYGPPG VGKTSAALAL
     ASEMDWDYIE LNASDQRTAE IIKSIAGPAS QVSTFSGRRR LVILDEADNL HGTYDRGGAA
     AILRVIKNAT QPVILIANEY YNIEKPLRDA CRGVQFRSIR AQTIASLLRE ICRSEGIECE
     PEAVMHIAAM SGGDLRSAIN DLEAAARGLK HLRLEDVATS ERDVKASIFR VLDSIFKGED
     SRSALEATYQ LDESPEDLIH WIDENLPIVY KDRELAKGFE CLSRADIFLG RVRRRQNYTL
     WRYAAFLMTG GVRAVSSKVR RGYTQFRPPS LWKRLGQTRK ARSVRDSAAR KIAAHCHVST
     SYARSELLNF VGALLRSKKT GAAVAASLGL NIEEIALLTG SSPTTKKVQK LFEDAQKIIE
     AEQIAMIDRG LKIVDREIEK PEDKAMKYAS VSKEIVQEKR QRSLFDF