ID   RFCL_METVS              Reviewed;         492 AA.
AC   A6URV8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Mevan_1333;
OS   Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS   / SB).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=406327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus vannielii SB.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000742; ABR55230.1; -; Genomic_DNA.
DR   RefSeq; WP_012066145.1; NC_009634.1.
DR   AlphaFoldDB; A6URV8; -.
DR   SMR; A6URV8; -.
DR   STRING; 406327.Mevan_1333; -.
DR   EnsemblBacteria; ABR55230; ABR55230; Mevan_1333.
DR   GeneID; 5324713; -.
DR   KEGG; mvn:Mevan_1333; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_0_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   Proteomes; UP000001107; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..492
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000318542"
FT   REGION          445..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..492
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   492 AA;  55317 MW;  FCE600EBCC2F81AB CRC64;
     MEEWVEKYRP KSLNDVAGHS KTKEALCYWI ESFIRGNKQK PVLLFGPPGS GKTTMAHAIA
     NDYNFDVIEL NASDKRNKDV ISQVVGTAAT SKSLTGKRTL IVLDEVDGLS GNDDRGGVSE
     IIKVLKNAEN PVILTANDVY KPALSSLRNS VTMVDAGSVH TNSIPPVLRK IALKEGFEID
     EKVIKLISSH AGGDLRAAIN DLQALLTGGS IEIEDAKNLP DRDSEKSIFD AIRIIMKTTH
     YDIATSATVD LKEELGTVSE WISENLPKEY LKYGDLAKGY DYLSKSDVFL GRVYRRQYFG
     LWRYASALMT AGTALSKEDK YRGFTRYSPP TVFTKLSRTK VAREKLKEIL KKIGIKTHTS
     IKGARSTLDF LYVIFESNLQ MATDLTLYYE FTKEEVEFLT NKKISKDIFS IIECEKTKKT
     DDKNLMKKDL EEDTFKEKTN EIMPVIPKRP KISDNQISEI LTKDNNPKDD VKKASKKPES
     TSKKQATLDK FF